21031-22-1

Usage

Chemical structure

A heterocyclic compound containing a pyrazole ring with a carboxylic acid group and a phenyl substituent.

Type of compound

Methyl ester derivative of 1H-pyrazole-4-carboxylic acid.

Usage

Commonly used in pharmaceutical research and development.

Potential applications

As a building block for the synthesis of new drug candidates in medicinal chemistry.

Suitability

Structure and properties make it suitable for the modification of existing pharmaceutical compounds or the development of novel therapeutic agents.

Biological activity

Has potential biological activity, contributing to its value in drug discovery and development processes.

Upstream product

• 186581-53-3 diazomethane 
• 4891-38-7 phenylpropynoic acid methyl ester 
• 67-56-1 methanol 
• 5504-65-4 3-phenyl-1H-pyrazole-4-carboxylic acid 
• 7299-58-3 phenylpropiolyl chloride 
• 96256-52-9 3-Phenyl-4-trifluoromethyl-1H-pyrazole 
• 772-62-3 3,3,3-trifluoro-1-phenylpropyne 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 97602-40-9 methyl (E)-3-(5-phenyl-2H-1,2,3,4-tetraazol-2-yl)-2-propenoate 

Downstream Products

• 5504-65-4 3-phenyl-1H-pyrazole-4-carboxylic acid 
• 80326-71-2 methyl 1-methyl-5-phenyl-1H-pyrazole-4-carboxylate 
• 90145-22-5 1-Methyl-3-phenylpyrazol-4-carbonsaeure-methylester 
• 1246895-08-8 methyl 1-(5-fluoropyridin-2-yl)-3-phenyl-1H-pyrazole-4-carboxylate 

Relevant academic research and scientific papers

P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN

The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X

Aminomethylene ketones and enamines in heterocyclic synthesis: Synthesis of functionally substituted pyridine, pyrazole, fused pyrimidine and fused [1,5]diazocine derivatives

Methyl 2-benzoyl-3-dimethylaminopropenoate (2) and 2-(benzimidazo-2-yl)-3- dimethylaminoacrylonitrile (27) were condensed with various type of reagents under different conditions to afford new acyclic, cyclic and fused heterocyclic derivatives.

Two-step Synthesis of Imidazoles from Activated Alkynes

Conjugate addition of 2-(tri-n-butylstannyl)tetrazoles (1) to activated alkynes gives 1-alkenyltetrazoles (4) and (5) predominantly.Use of the N-tributylstannyl derivatives, rather than the parent tetrazole, gives a high ratio of 1- to 2-alkenyl isomers and avoids the complication of further addition of the tetrazole or the alkyne to the initial adduct.Irradiation of the (Z)- and (E)-1-alkenyltetrazoles (4) and (5) at 254 nm then gives the expected imidazoles in moderate yield.However, 5-phenyl-2-(tri-n-butylstannyl)tetrazole (1a) reacted only slowly with ethyl phenylpropiolate to give ethyl 3,5-diphenylpyrazole-4-carboxylate (8), presumably via the 2-alkenyltetrazole (9) formed in preference to the 1-isomer for steric reasons.

Studies on Organic Fluorine Compounds. XLII. Synthesis and Reactions of Phenyltrifluoromethylacetylenes

Phenyltrifluoromethylacetylene (4a) was synthesized by the pyrolysis of triphenylphosphonium α-(trifluoroacetyl)benzylide (3a), which was easily derived from benzyl halide (1a).This method can be used for the synthesis of 4-substituted-phenyltrifluoromethylacetylenes (4).The 1,3-dipolar reaction of 4 with diazomethane and phenyl azide proceeds readily to give trifluoromethylated pyrazoles and triazoles.Keywords - trifluoromethyl; acetylene; 1,3-dipolar reaction; intramolecular Wittig reaction; trifluoroacetylphosphonium ylide; pyrazole; diazomethane; phenyl azide