210360-63-7Relevant academic research and scientific papers
Synthesis of anabasine-containing aminomethyl derivatives of 6-hydroxyaurones
Popova, Antonina V.,Bondarenko, Svitlana P.,Vinogradova, Valentina I.,Frasinyuk, Mykhaylo S.
, p. 212 - 216 (2019/05/15)
[Figure not available: see fulltext.] Aminomethylation of aurones was studied by using anabasine. The reaction in the case of 6-hydroxyaurones was shown to selectively provide 7-aminomethyl-6-hydroxyaurones, while 5-aminomethyl-6-hydroxy-7-methylaurones could be obtained by transamination of 5-dimethylaminomethyl derivatives of 6-hydroxy-7-methylaurones in the presence of anabasine.
Synthesis of aminoalkyl-substituted aurone derivatives as acetylcholinesterase inhibitors
Lee, Young Hun,Shin, Min Cheol,Yun, Yong Don,Shin, Seo Young,Kim, Jong Min,Seo, Jeong Moo,Kim, Nam-Jung,Ryu, Jong Hoon,Lee, Yong Sup
, p. 231 - 240 (2015/02/18)
Alzheimer's disease (AD), a progressive and neurodegenerative disorder of the brain, is the most common cause of dementia among elderly people. To date, the successful therapeutic strategy to treat AD is maintaining the levels of acetylcholine by inhibiting acetylcholinesterase (AChE). In the present study, aurone derivatives were designed and synthesized as AChE inhibitors based on the lead structure of sulfuretin. Of those synthesized, compound 10d showed ca. 1700-fold and 6-fold higher AChE inhibitory activity than sulfuretin and galantamine, respectively. This compound also ameliorated scopolamine-induced memory deficit in mice when administered orally at the dose of 1 and 2 mg/kg.
Benzofuranone derivatives and a method for producing them
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, (2008/06/13)
PCT No. PCT/JP98/00090 Sec. 371 Date Dec. 7, 1998 Sec. 102(e) Date Dec. 7, 1998 PCT Filed Jan. 13, 1998 PCT Pub. No. WO98/30556 PCT Pub. Date Jul. 16, 1998The present invention provides new benzofuranone derivatives and a method for producing the derivatives useful for a therapeutic agent for preventing and/or treating hormone dependent diseases. The present invention is a new benzofuranone derivative represented by a particular general formula (I). In the production, a particular benzofuranone compound and a particular benzaldehyde are reacted.
