210364-40-2Relevant academic research and scientific papers
Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones
Gleave, D. Mark,Brickner, Steven J.,Manninen, Peter R.,Allwine, Debra A.,Lovasz, Kristine D.,Rohrer, Douglas C.,Tucker, John A.,Zurenko, Gary E.,Ford, Charles W.
, p. 1231 - 1236 (1998)
A series of conformationally restricted, [6,5,5] and [6,6,5] tricyclic fused oxazolidinones were synthesized and tested for antibacterial activity. Several compounds in the trans-[6,5,5] series demonstrated potent in vitro and in vivo activity. This work provides valuable information regarding the preferred conformational orientation of the oxazolidinones at the binding site.
