3456-75-5

Usage

Uses

Used in Pharmaceutical Industry:
5-Fluoro-2-nitrophenylacetonitrile is used as a key intermediate in the synthesis of various bioactive compounds and potential drug candidates. Its unique structure, featuring a fluorine atom and a nitro group, allows for the development of novel therapeutic agents with improved pharmacological properties.
Used in Organic Synthesis:
In the field of organic synthesis, 5-Fluoro-2-nitrophenylacetonitrile serves as a valuable building block for the preparation of a wide range of chemical compounds. Its reactivity and functional groups enable the formation of diverse molecular structures, contributing to the advancement of chemical research and the discovery of new materials.
Used in Chemical Reactions:
5-Fluoro-2-nitrophenylacetonitrile is employed as a reactant in various chemical reactions, facilitating the formation of new compounds with specific properties. Its presence in these reactions can influence the reaction pathways and outcomes, leading to the synthesis of desired products with potential applications in different industries.
Used in Research and Development:
In research and development settings, 5-Fluoro-2-nitrophenylacetonitrile is utilized as a starting material for the exploration of new chemical reactions and the synthesis of novel compounds. Its unique structural features make it an attractive candidate for studying reaction mechanisms and developing innovative synthetic strategies.
Used in Material Science:
5-Fluoro-2-nitrophenylacetonitrile can be incorporated into the development of new materials with specific properties, such as improved thermal stability, enhanced chemical resistance, or unique optical characteristics. Its incorporation into polymers, coatings, or other materials can lead to the creation of advanced materials with potential applications in various industries.

InChI:InChI=1/C8H5FN2O2/c9-7-1-2-8(11(12)13)6(5-7)3-4-10/h1-2,5H,3H2

Upstream product

• 107-14-2 chloroacetonitrile 
• 350-46-9 4-Fluoronitrobenzene 
• 501-00-8 3-fluorophenylacetonitrile 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 3598-13-8 (4-chlorophenoxy)acetonitrile 
• 352-70-5 m-Fluorotoluene 

Downstream Products

• 152562-00-0 (Z)-2-(5-Fluoro-2-nitro-phenyl)-but-2-enenitrile 
• 210364-40-2 (5-Morpholin-4-yl-2-nitro-phenyl)-acetonitrile 
• 1259405-84-9 (5-fluoro-2-nitrophenyl)(1-methylpyrrolidin-2-ylidene)acetonitrile 
• 1416438-82-8 C₁₆H₉FN₂ 
• 1417791-44-6 2-(5-fluoro-2-nitrophenyl)-4-oxo-4-phenylbutyronitrile 
• 399-52-0 5-fluoro-1H-indole 

Relevant academic research and scientific papers

Modular Synthesis of Polysubstituted Quinolin-3-amines by Oxidative Cyclization of 2-(2-Isocyanophenyl)acetonitriles with Organoboron Reagents

Polysubstituted quinolin-3-amines are vital structural motifs because of their broad biological activities as well as versatile transformational abilities. However, they are not easily accessible. We disclose a protocol with Mn(III) acetate as a mild one-

NOVEL CYCLIC AMIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE

The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compo

Active and Recyclable Catalytic Synthesis of Indoles by Reductive Cyclization of 2-(2-Nitroaryl)acetonitriles in the Presence of Co-Rh Heterobimetallic Nanoparticles with Atmospheric Hydrogen under Mild Conditions

A cobalt-rhodium heterobimetallic nanoparticle-catalyzed reductive cyclization of 2-(2-nitroaryl)acetonitriles to indoles has been achieved. The tandem reaction proceeds without any additives under the mild conditions (1 atm H2 and 25 °C). This procedure could be scaled up to the gram scale. The catalytic system is significantly stable under these reaction conditions and could be reused more than ten times without loss of catalytic activity.

Short and simple method of synthesis of some pyrrolo[3,2-b]quinoline derivatives from easily available nitrobenzene derivatives

The Vilsmeier-Hack condensation of ortho-cyanomethylated nitroarenes with N-methylpyrrolidone, followed by cyclization promoted by O,N- bistrimethylsilylacetamide and DBU in DMF led directly to pyrrolo[3,2-b] quinoline derivatives. Georg Thieme Verlag Stuttgart · New York.

Specific ortho-Cyanomethylation of Nitroarenes via the Vicarious Nucleophilic Substitution of Hydrogen

The vicarious nucleophilic substitution of hydrogen in nitroarenes with acetonitrile derivatives XCH2CN in t-BuOK/THF base/solvent system proceeds exclusively ortho to the nitro group.Strong influence of substituents Z in 3-Z-nitrobenzene derivatives on the orientation has been observed.