Bioorganic and Medicinal Chemistry Letters p. 1231 - 1236 (1998)
Update date:2022-08-03
Topics:
Gleave, D. Mark
Brickner, Steven J.
Manninen, Peter R.
Allwine, Debra A.
Lovasz, Kristine D.
Rohrer, Douglas C.
Tucker, John A.
Zurenko, Gary E.
Ford, Charles W.
A series of conformationally restricted, [6,5,5] and [6,6,5] tricyclic fused oxazolidinones were synthesized and tested for antibacterial activity. Several compounds in the trans-[6,5,5] series demonstrated potent in vitro and in vivo activity. This work provides valuable information regarding the preferred conformational orientation of the oxazolidinones at the binding site.
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(1998)
