2104-00-9

Basic information

• Product Name: LABOTEST-BB LT01281636
• Synonyms: SALOR-INT L481394-1EA;LABOTEST-BB LT01281636;4-(4-CHLOROPHENYL)-1,3-THIAZOLE-2-THIOL;4-(4-Chlorophenyl)-4-thiazoline-2-thione;2-thiazolethiol, 4-(4-chlorophenyl)-;4-(4-chlorophenyl)-3H-1,3-thiazole-2-thione;4-(4-chlorophenyl)-3H-thiazole-2-thione;4-(4-Chloro-phenyl)-thiazole-2-thiol
• CAS NO: 2104-00-9
• Molecular Formula: C₉H₆ClNS₂
• Molecular Weight: 227.73
• Mol File: 2104-00-9.mol

Chemical Properties

• Boiling Point: 359.3 °C at 760 mmHg
• Flash Point: 171.1 °C
• Appearance: /
• Density: 1.49
• CAS DataBase Reference: LABOTEST-BB LT01281636(CAS DataBase Reference)
• NIST Chemistry Reference: LABOTEST-BB LT01281636(2104-00-9)
• EPA Substance Registry System: LABOTEST-BB LT01281636(2104-00-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 2104-00-9(Hazardous Substances Data)

Usage

Uses

Used in the Cosmetic Industry:
LABOTEST-BB LT01281636 is used as a conditioning agent and emollient for its moisturizing and lubricating properties, making it a popular ingredient in lotions, creams, and hair care products.
Used in the Fragrance Industry:
In the realm of perfumes and other scented products, LABOTEST-BB LT01281636 is utilized as a fragrance ingredient, capitalizing on its mild and pleasant odor to enhance the sensory experience of these products.

Upstream product

• 333-20-0 potassium thioacyanate 
• 99-91-2 para-chloroacetophenone 
• 17356-08-0 thiourea 
• 513-74-6 ammonium dithiocarbamate 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 25917-49-1 1-(4-chlorophenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 123466-28-4 [(4-chlorophenyl)ethynyl](phenyl)iodonium tosylate 
• 94210-44-3 2,2'-bis[4-(p-chlorophenyl)thiazyl]disulfide 
• 352200-57-8 N-(5-methyl-1-phenyl-4-hexen-1-oxy)-4-(p-chlorophenyl)-thiazole-2(3H)-thione 
• 22535-06-4 p-chloro-phenacyl bromide 
• 54608-14-9 ammonium dithiocarbonate 
• 507-09-5 thioacetic acid 
• 19339-59-4 1-(4-chloro-phenyl)-2-thiocyanato-ethanone 

Downstream Products

• 105469-45-2 3a,3b-Bis-(4-chloro-phenyl)-hexahydro-1,6-dithia-3,4-diaza-cyclobutadicyclopentene-2,5-dithione 
• 97340-38-0 4-(4-chloro-phenyl)-2-(2-nitro-phenyldisulfanyl)-thiazole 
• 130459-60-8 [4-(4-Chloro-phenyl)-thiazol-2-ylsulfanyl]-acetonitrile 
• 130459-70-0 3-[4-(4-Chloro-phenyl)-thiazol-2-ylsulfanyl]-chromen-2-one 
• 130459-64-2 3-[4-(4-Chloro-phenyl)-thiazol-2-ylsulfanyl]-chromen-2-ylideneamine 
• 130459-68-6 3-[4-(4-Chloro-phenyl)-thiazol-2-ylsulfanyl]-8-methoxy-chromen-2-ylideneamine 
• 130459-72-2 3-[4-(4-Chloro-phenyl)-thiazol-2-ylsulfanyl]-8-methoxy-chromen-2-one 
• 97284-39-4 4-(4-chloro-phenyl)-2-(2-chloro-phenyldisulfanyl)-thiazole 
• 97319-78-3 2-(4-chloro-2-nitro-phenyldisulfanyl)-4-(4-chloro-phenyl)-thiazole 
• 97556-32-6 4-(4-chloro-phenyl)-2-p-tolyldisulfanyl-thiazole 
• 97340-37-9 4-(4-chloro-phenyl)-2-(4-nitro-phenyldisulfanyl)-thiazole 
• 97284-40-7 4-(4-chloro-phenyl)-2-(4-chloro-phenyldisulfanyl)-thiazole 
• 97833-30-2 4-(4-chloro-phenyl)-2-phenyldisulfanyl-thiazole 
• 2103-97-1 4-(4-chlorophenyl)-2-(methylthio)thiazole 

Relevant articles and documents

Synthesis of novel azabicyclo derivatives containing a thiazole moiety and their biological activity against pine-wood nematodes

To explore a new skeleton with nematicidal activity, a series of novel azabicyclo derivatives containing a thiazole moiety were designed, synthesized and evaluated for their nematicidal activities. The bioassay results against pine-wood nematodes (Bursaphelenchus xylophilus) showed that most of the title compounds displayed nematicidal activity at a concentration of 40 mg/L. Especially, the title compounds2-((8-methyl-8-azabicyclo[3.2.1]octan-3-yl)oxy)-4-(4-chlorophenyl)thiazole (7e), 2-((8-methyl-8-azabicyclo[3.2.1]octan-3-yl)thio)-4-phenylthiazole (10a) and 2-((8-methyl-8-azabicyclo [3.2.1]octan-3-yl)thio)-4-(4-chlorophenyl)thiazole (10e) exhibited more than 90% mortality against Bursaphelenchus xylophilus.

Synthesis of 4- and 5-arylthiazolinethiones as inhibitors of indoleamine 2,3-dioxygenase

Docking studies of 4-phenylthiazolinethione on human IDO1 suggest complexation of the heme iron by the exocyclic sulfur atom further reinforced by hydrophobic interactions of the phenyl ring within pocket A of the enzyme. On this basis, chemical modifications were proposed to increase inhibition activity. Synthetic routes had to be adapted and optimized to yield the desired substituted 4- and 5-arylthiazolinethiones. Their biological evaluation shows that 5-aryl regioisomers are systematically less potent than the corresponding 4-aryl analogs. Substitution on the phenyl ring does not significantly increase inhibition potency, except for 4-Br and 4-Cl derivatives.

2-[3H-THIAZOL-2-YLIDINEMETHYL]PYRIDINES AND RELATED COMPOUNDS AND THEIR USE

The present invention pertains to certain 2-[3H-thiazol-2-ylidinemethyl]pyridine compounds and analogs thereof, which, inter alia, inhibit cell proliferation, treat cancer, etc., and more specifically to compounds of the following formula, wherein RA1, RA2, RA3, RA4, RB1, RB2, RNA, RNB, and X? are as defined herein: The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cell proliferation, and in the treatment of proliferative conditions such as cancer, etc.

Lessons of 3-alkoxy-4-(p-chlorophenyl)4,3-thiazole-2(3H)-thione chemistry learned from structural investigations

Synthetic, spectroscopic, and structural investigations provided evidence that distinguished neat 3-alkoxy-4-(p-chlorophenyl)-l,3-thiazole-2(3H)-thiones (CPTTORs), once developed to serve as alkoxyl radical precursors for storage and use on demand, showed

A facile synthesis of thiazole-2(3H)-thiones through [hydroxy(tosyloxy) iodo]benzene

A one-pot facile synthesis of thiazole-2(3H)-thiones (4) has been achieved by hypervalent iodine oxidation of ketones (1) using [hydroxy (tosyloxy)iodo]benzene, followed by the treatment of the reaction mixture with dithiocarbamate salts (3) The intermediate α-tosyloxy-ketones (2) have also been isolated and converted to the target compounds.

Synthesis and evaluation of some substituted mercaptothiazoles and their derivatives of biological interest

The title compounds have been synthesized from 4-(4′ -chlorophenyl)-Δ4-thiazoline-2-thione1, which in turn is synthesized by the reaction of p-chlorophenacyl bromide with ammonium dithiocarbamate. Compound 1 on treatment with N-chlor

Hypervalent iodine in synthesis. 48. A one-pot convenient procedure for the synthesis of 2-mercaptothiazoles by cyclocondensation of ketones with [hydroxy(tosyloxy)iodo]-benzene and ammonium dithiocarbamate

α-Tosyloxylation of ketones with [hydroxy(tosyloxy)iodo]-benzene (HTIB), followed by treatment with ammonium dithiocarbamate, provides a one-pot convenient procedure for the synthesis of 2-mercaptothiazoles with good yields.

Hypervalent iodine in synthesis; 60: A novel method for the synthesis of 2-mercaptothiazoles by cyclocondensation of alkynyl(phenyl)iodonium salts and ammonium dithiocarbamate

A novel method for the synthesis of 2-mercaptothiazoles is achieved by cyclocondensation of alkynyl(phenyl)iodonium salts with ammonium dithiocarbamate. A reaction mechanism is proposed.

Photoreactions of N-alkoxy-4-(p-chlorophenyl)thiazole-2(3H)-thiones with L-cysteine derivatives in aqueous solutions

Photolysis of substituted N-alkoxythiazolethiones 1 in aqueous solvents furnishes alkoxyl radicals 2 which, upon stereoselective 5-exo-trig cyclization, are trapped by water soluble thiols (L-cysteine, L-cysteine ethyl ester, or the reduced form of glutathione, GSH) to afford disubstituted tetrahydrofurans 3 in synthetically useful yields and with satisfactory to excellent diastereoselectivities.

N-hydroxy-4-(4-chlorophenyl)thiazole-2(3H)-thione as a photochemical hydroxyl-radical source: Photochemistry and oxidative damage of DNA (strand breaks) and 2′-deoxyguanosine (8-oxodG formation)

On irradiation of N-hydroxythiazole-2(3H)-thione 3 at 300 nm, the photoproducts disulfide 4, bisthiazole 5 and thiazole 6 are formed. During this photolysis, hydroxyl radicals are released, which have been detected by spin trapping with 5,5-dimethyl-1-pyrroline N-oxide (DMPO), coupled with electron paramagnetic resonance spectroscopy. In the presence of supercoiled pBR322 DNA, irradiation of thiazolethione 3 induces strand breaks through the photogenerated hydroxyl-radicals, as confirmed by control experiment with the hydroxyl-radical scavenger isopropanol. Singlet oxygen appears not to be involved, as attested by the lack of a D2O isotope effect. During the photoreaction of thiazolethione 3 in the presence of 2′-deoxyguanosine (dG), the latter is photooxidized (ca 10% conversion after 2 h of irradiation) to the 7,8-dihydro-8-oxo-2′-deoxyguanosine as the main oxidation product. The dG conversion levels off after complete consumption of thiazolethione 3 and is suppressed by the addition of the hydroxyl-radical scavenger 2,6-di-tert-butylcresol or DMPO. Since the photoproducts 4-6 are ineffective as sensitizers for the photooxidation of dG and DNA, the hydroxyl radicals released in the photolysis of thiazolethione 3 are the oxidizing species of DNA and dG. These results suggest that the thiazolethione 3 may serve as a novel and effective photochemical hydroxyl-radical source for photobiological studies.