210555-50-3

Basic information

• Product Name: C₁₆H₂₈O₃Si
• Synonyms: C₁₆H₂₈O₃Si
• CAS NO: 210555-50-3
• Molecular Weight: 296.482
• Mol File: 210555-50-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₁₆H₂₈O₃Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₂₈O₃Si(210555-50-3)
• EPA Substance Registry System: C₁₆H₂₈O₃Si(210555-50-3)

Safety Data

• Hazardous Substances Data: 210555-50-3(Hazardous Substances Data)

Upstream product

• 6997-34-8 1-(4-hydroxy-3-methoxyphenyl)propan-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 121-33-5 vanillin 
• 69404-94-0 O-tert-butyldimethylsilylvanillin 
• 925-90-6 ethylmagnesium bromide 

Downstream Products

• 10035-17-3 2-bromo-1-(4-hydroxy-3-methoxy-phenyl)-propan-1-one 
• 97-54-1 2-methoxy-4-propenylphenol 

Relevant articles and documents

Identification of a Novel TRPM8 Agonist from Nutmeg: A Promising Cooling Compound

The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary receptor for innocuous cold stimuli (8′-7-ethoxy-4-hydroxy-3,3′,5′-trimethoxy-8-O-4′-neolignan (1) with an EC50 of 0.332 μM, which was isolated from a well-known spice, nutmeg (Myristica fragrans Houtt.). Structure activity relationships are also disclosed, showing that the 7-d-menthoxy derivative is the most potent agonist (EC50 = 11 nM). The combination of 1 and l-(-)-menthol has an additive effect, suggesting that neolignan compounds interact with TRPM8 at different sites from those of l-(-)-menthol.

A novel synthesis of isoeugenol, [ring-(U)-14C]

A novel method for the preparation of isoeugenol, [ring-(U)-14C] is presented. Phenols and phenyl esters substituted in the para position with 1-hydroxyethyl or 1-hydroxypropyl acetate esters when treated with 1,8-diazabicyclo[5.4.0]undec-7-ene in dimethylformamide (DMF) eliminate the alkyl carboxylate function to give the unsaturated compound. The reaction fails with unsubstituted or ether substituted phenyl 1-hydroxyacetate esters.