210555-50-3Relevant academic research and scientific papers
Identification of a Novel TRPM8 Agonist from Nutmeg: A Promising Cooling Compound
Shirai, Tomohiro,Kumihashi, Kentaro,Sakasai, Mitsuyoshi,Kusuoku, Hiroshi,Shibuya, Yusuke,Ohuchi, Atsushi
, p. 715 - 719 (2017)
The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary receptor for innocuous cold stimuli (8′-7-ethoxy-4-hydroxy-3,3′,5′-trimethoxy-8-O-4′-neolignan (1) with an EC50 of 0.332 μM, which was isolated from a well-known spice, nutmeg (Myristica fragrans Houtt.). Structure activity relationships are also disclosed, showing that the 7-d-menthoxy derivative is the most potent agonist (EC50 = 11 nM). The combination of 1 and l-(-)-menthol has an additive effect, suggesting that neolignan compounds interact with TRPM8 at different sites from those of l-(-)-menthol.
Flavor composition
-
, (2017/12/27)
PROBLEM TO BE SOLVED: To provide a flavoring composition comprising a novel compound useful for giving a cold sensation and a flavor giving method using the flavoring composition.SOLUTION: A compound represented by formula (I) is contained in an amount of
A novel synthesis of isoeugenol, [ring-(U)-14C]
Immoos, John E.
, p. 419 - 424 (2015/11/18)
A novel method for the preparation of isoeugenol, [ring-(U)-14C] is presented. Phenols and phenyl esters substituted in the para position with 1-hydroxyethyl or 1-hydroxypropyl acetate esters when treated with 1,8-diazabicyclo[5.4.0]undec-7-ene in dimethylformamide (DMF) eliminate the alkyl carboxylate function to give the unsaturated compound. The reaction fails with unsubstituted or ether substituted phenyl 1-hydroxyacetate esters.
Cooling Agent and TRPM8 Activator
-
, (2014/11/13)
Provided are a cooling agent having an excellent TRPM8 activating action, a TRPM8 activator, a method for imparting cooling sensation, and a novel compound useful for imparting cooling sensation. Disclosed is a cooling agent comprising, as an active ingre
