21056-77-9

Basic information

• Product Name: ethyl 1H-pyrazole-5(3)-carboxylate
• Synonyms: ethyl 1H-pyrazole-5(3)-carboxylate;EOS-62297
• CAS NO: 21056-77-9
• Molecular Formula: C₆H₈N₂O₂
• Mol File: 21056-77-9.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 1H-pyrazole-5(3)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1H-pyrazole-5(3)-carboxylate(21056-77-9)
• EPA Substance Registry System: ethyl 1H-pyrazole-5(3)-carboxylate(21056-77-9)

Safety Data

• Hazardous Substances Data: 21056-77-9(Hazardous Substances Data)

Usage

General Description

Ethyl 1H-pyrazole-5(3)-carboxylate is a chemical compound with the molecular formula C7H8N2O2. It is a derivative of pyrazole and has a carboxylic acid group attached to the 5(3) position of the ring. ethyl 1H-pyrazole-5(3)-carboxylate is commonly used in organic synthesis and medicinal chemistry as a building block for the production of various pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a precursor in the synthesis of pyrazole-based dyes and pigments. Ethyl 1H-pyrazole-5(3)-carboxylate has potential applications in the development of new drugs and agrochemicals due to its unique chemical structure and reactivity.

Upstream product

• 181427-25-8 ethyl (E)-4-(dimethylamino)-2-oxo-but-3-enoate 
• 64-17-5 ethanol 
• 1621-91-6 1H-pyrazole-3-carboxylic acid 
• 1621-91-6 1-2H-pyrazole-3-carboxylic acid 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 59938-07-7 (3E)-1,1,1-trichloro-4-ethoxybut-3-en-2-one 

Downstream Products

• 1313409-96-9 ethyl 1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate 
• 951626-38-3 6,7-dihydro-pyrazolo[1,5-a] pyrazin-4(5H)-one 
• 115315-94-1 ethyl 1-phenyl-1H-pyrazole-5-carboxylate 
• 1621-91-6 1-2H-pyrazole-3-carboxylic acid 
• 174907-58-5 ethyl 1-benzyl-1H-pyrazole-3-carboxylate 

Relevant articles and documents

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Gold(I)-Catalyzed Reactions between 2-(1-Alkynyl)-2-alken-1-ones and Vinyldiazo Ketones for Divergent Synthesis of Nonsymmetric Heteroaryl-Substituted Triarylmethanes: N-versus C-Attack Paths

Gold-catalyzed synthesis of nonsymmetrical heteroaryl-substituted triarylmethanes using 2-(1-alkynyl)-2-alken-1-ones and vinyldiazo ketones is described. In this catalytic sequence, vinyldiazo ketones attack gold-containing 3-furylbenzyl cations to form the observed C(1)-addition products. We also note that vinyldiazo ketones can be thermally cyclized to yield pyrazole derivatives, which can react with 3-furylbenzyl cations to afford pyrazole-containing triarylmethanes, corresponding to a N(5)-addition path.

6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 ("mGluR2"). The invention is also directed to pharmaceutical compositi