21058-56-0

Basic information

• Product Name: 8-hydroxy-5a,7a-dimethyl-4,5,5a,5b,6,7,7a,8,9,10,10a,10b,11,12-tetradecahydrocyclopenta[5,6]naphtho[1,2-d]azepin-2(3H)-one
• Synonyms: cyclopenta[5,6]naphth[1,2-d]azepin-2(3H)-one, 4,5,5a,5b,6,7,7a,8,9,10,10a,10b,11,12-tetradecahydro-8-hydroxy-5a,7a-dimethyl-
• CAS NO: 21058-56-0
• Molecular Formula: C₁₉H₂₉NO₂
• Molecular Weight: 303.4391
• Mol File: 21058-56-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 500.7°C at 760 mmHg
• Flash Point: 256.6°C
• Density: 1.14g/cm³
• Vapor Pressure: 4E-12mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 8-hydroxy-5a,7a-dimethyl-4,5,5a,5b,6,7,7a,8,9,10,10a,10b,11,12-tetradecahydrocyclopenta[5,6]naphtho[1,2-d]azepin-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-hydroxy-5a,7a-dimethyl-4,5,5a,5b,6,7,7a,8,9,10,10a,10b,11,12-tetradecahydrocyclopenta[5,6]naphtho[1,2-d]azepin-2(3H)-one(21058-56-0)
• EPA Substance Registry System: 8-hydroxy-5a,7a-dimethyl-4,5,5a,5b,6,7,7a,8,9,10,10a,10b,11,12-tetradecahydrocyclopenta[5,6]naphtho[1,2-d]azepin-2(3H)-one(21058-56-0)

Safety Data

• Hazardous Substances Data: 21058-56-0(Hazardous Substances Data)

Upstream product

• 1045-69-8 testosterone acetate 
• 59285-18-6 17β-acetoxy-3-hydroximinoandrost-4-ene 
• 21058-55-9 3-aza-17β-acetoxy-A-homo-4α-androsten-4-one 

Downstream Products

• 99876-94-5 17β-hydroxy-3-aza-A-homo-4a-androsten-4-one pphenylbutyrate 
• 21058-62-8 3-aza-A-homo-4α-androsten-4,17-dione oxime 
• 5044-10-0 3,17α-diaza-A,D-bishomoandrost-4α-ene-4,17-dione 
• 75921-67-4 4-oxo-3-aza-A-homo-4a-androsten-17β-yl-N-p-(bis-2-chloroethylamino)phenylcarbamate 
• 20986-87-2 3-aza-A-homo-4α-androstene-4,17-dione 
• 86270-47-5 17β-hydroxy-3-aza-A-homo-4a-androsten-4-one p-phenylacetate 
• 99876-93-4 17β-hydroxy-3-aza-A-homo-4a-androsten-4-one pphenylthioacetate 

Relevant articles and documents

ESTERS OF STEROIDAL LACTAM AND BIS(2-CHLOROETHYL) AMINOPHENOXY PROPANOIC ACID DERIVATIVES

Novel homo-aza-steroidal esters with alkylating bis(2-chloroethyl)aminophenoxy propanoic acid and substituted derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of cancer.

Beckmann rearrangement of 3-aza-A-homo-4α-androsten-4,17-dione oxime and 3-oxo-13α-amino-13,17-seco-4-androsten-17-oic 13,17-lactam oxime

Rearragements of 3-aza-A-homo-4α-androsten-4,17-dione oxime produced a mixture of the normal lactam product and the product of a 'second order' cleavage, an unsaturated nitrile. The lactam 3,17α-diaza-A,D-bishomoandrost-4α-ene-4,17-dione was also obtained from the rearrangement of the syn-3-oxo-13α-amino-13,17-seco-4-androsten-17-oic-13,17-lactam oxime. The resolution of syn- and anti-isomers of VIII was effected by column chromatography and their structure was determined by spectral data.