210581-14-9Relevant academic research and scientific papers
Two-step N-acylindazole to N-alkylindazole reduction. Further synthetic studies on the serotonergic agonist AL-34662
Conrow, Raymond E.,Delgado, Pete,Dean, W. Dennis,Callen, Gary R.,Plummer, Scott V.
, p. 2348 - 2350 (2008/09/18)
A synthesis of the title compound, operable on kilogram scale, employs reductive acetylation of an N-acylindazole to give a hemiaminal acetate followed by deacetoxylation to the corresponding N-alkylindazole.
1-((S)-2-aminopropyl)-1H-indazol-6-ol: A potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity
May, Jesse A.,Dantanarayana, Anura P.,Zinke, Paul W.,McLaughlin, Marsha A.,Sharif, Najam A.
, p. 318 - 328 (2007/10/03)
Serotonin 5-HT2 receptor agonists have been identified as a potential new class of agents for the treatment of ocular hypertension and glaucoma. The initially reported tryptamine analogues displayed either poor solution stability, potent centra
1-ALKYL-3-AMINOINDAZOLES
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Page 10, (2008/06/13)
Methods of making 1-alkylindazoles are described. The methods involve reacting a 2-alkylaminobenzonitrile with a nitrosating agent followed by reduction-cyclization of the resulting nitrosamine to form a 1-alkyl-3-aminoindazole. The 1-alkyl-3-aminoinda
PYRANOINDAZOLES AND THEIR USE FOR THE TREATMENT OF GLAUCOMA
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, (2010/11/29)
Pyranoindazoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the prese
