21066-20-6

Upstream product

• 15073-97-9 methyl 3α,12α-dihydroxy-7-oxo-5β-cholate 
• 108-24-7 acetic anhydride 
• 21059-39-2 methyl 3α-acetyloxy-7-oxo-12α-hydroxy-5β-cholan-24-oate 
• 7443-91-6 methyl cholate 3-acetate 
• 81-25-4 cholic acid 
• 911-40-0 7-ketodeoxycholic acid 
• 1448-36-8 methyl cholate 

Downstream Products

• 58822-33-6 methyl 3α,12α-diacetyloxy-7α-hydroxy-5β-cholan-24-oate 
• 83-44-3 Deoxycholic acid 
• 911-40-0 7-ketodeoxycholic acid 
• 133181-56-3 methyl 12α-acetoxy-3α,6α-dihydroxy-7-oxo-5β-cholanoate 
• 133181-57-4 methyl 12α-acetoxy-3α,6α,7α-trihydroxy-5β-cholanoate 
• 75110-48-4 3α,6β,7β,12α-tetrahydroxy-5β-cholan-24-oic acid 
• 80875-93-0 3α,6β,7α,12α-tetrahydroxy-5β-cholan-24-oic acid 
• 62681-12-3 3α,12α-diacetoxy-5β-chol-6-enoic acid 
• 152953-43-0 Biphenyl-4-carboxylic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-12-acetoxy-3-acryloyloxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-yl ester 
• 161882-44-6 Biphenyl-4-carboxylic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,12-diacetoxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-yl ester 
• 161882-45-7 Biphenyl-4-carboxylic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-12-acetoxy-3-hydroxy-17-((R)-3-methoxycarbonyl-1-methyl-propyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-yl ester 
• 318473-19-7 (R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,12-Diacetoxy-10,13-dimethyl-7-(2-oxo-2-phenyl-acetoxy)-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid methyl ester 

Relevant academic research and scientific papers

POLYHYDROXYLATED BILE ACIDS FOR TREATMENT OF BILIARY DISORDERS

The invention provides, in part, polyhydroxylated bile acids for treating biliary disorders, for example, biliary disorders arising out of cholestasis or portal hypertesion. The invention also provides, in part, polyhydroxylated bile acids for stimulating bile flow. New compounds 2α,3α,7α,12α-tetrahydroxy-5β-cholanoic acid and 3α,4α,7α,12α-tetrahydroxy-5β-cholanoic acid are disclosed, uses thereof and synthesis thereof.

Asymmetric induction by the cholestanic moiety on Tropos species: Synthesis and stereochemical characterization of bile acid-based biphenyl phosphites

Three different bile acid-derived biphenyl phosphites were synthesized, starting from cholic and deoxycholic acids and biphenol, and their stereochemical features were checked by CD and NMR spectroscopies. On the basis of the spectroscopic results, the ca

Synthesis of both enantiomers of 1-phenylethane-1,2-diol via chirality transfer from bile acid derivatives

Both enantiomers of 1-phenylethane-1,2-diol were synthesized with good to excellent enantioselectivities via selective reduction of the phenylglyoxalates derived from bile acids, followed by reductive cleavage. Copyright (C) 2000 Elsevier Science Ltd.

Asymmetric Diels-Alder reactions of chiral acrylates of cholic acid derivatives

New steroid-based chiral auxiliaries 6, 9, and 12 have been synthesized from readily available cholic acid. These new chiral auxiliaries place the reactive and the shielding sites in a 1,5 relationship to each other. Diels-Alder reaction of cyclopentadien

Cholic Acid Derived Novel Chiral Auxiliaries for Asymmetric Diels-Alder Reactions

Cholic acid-based chiral acrylate 5 yields a Diels-Alder adduct with cyclopentadiene in the presence of BF3*OEt2 with 88 percent diastereoselectivity

An efficient synthesis of 4β and 6α-hydroxylated bile acids

An efficient method for the preparation of 4β- and 6α-hydroxylated bile acids has been developed.It involved a highly stereoselective acetoxylation at the 4β and 6α positions of 3- and 7-oxo bile acids, respectively, with lead tetraacetate in the presence of boron trifluoride etherate in acetic acid.Reduction of the resulting α-acetoxy ketones with sodium borohydride or tert-butylamine borane complex, and alkaline hydrolysis, provided the desired bile acids in good yields. Keywords: sterols; bile acid; 4β-hydroxylated bile acid;6α-hydroxylated bile acid; acetoxylation; lead tetraacetate oxidation