Bioorganic and Medicinal Chemistry Letters p. 1499 - 1502 (1998)
Update date:2022-09-26
Topics:
Belliotti, Thomas R.
Brink, Wouter A.
Kesten, Suzanne R.
Rubin, John R.
Wustrow, David J.
Zoski, Kim T.
Whetzel, Steven Z.
Corbin, Ann E.
Pugsley, Thomas A.
Heffner, Thomas G.
Wise, Lawrence D.
PD 108635 (1) was identified as a potent dopamine D4 ligand and we wanted to replace the benzylic alcohol with a metabolically more stable moiety. Investigations led to the discovery of a series of isoindolinones having D4 affinity.
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Doi:10.1246/bcsj.41.2960
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(1998)
