210689-29-5

Upstream product

• 115094-43-4 5'-O-(tert-butyldimethylsilyl)-2'-O-(p-tolylsulfonyl)adenosine 
• 58-61-7 adenosine 
• 151725-86-9 9-(5-O-tert-butyldimethylsilyl-2-deoxy-β-D-threo-pentofuranosyl)adenine 
• 69530-93-4 5'-(O-tert-butyldimethylsilyl)adenosine 
• 87418-35-7 9-(2',3'-dideoxy-3'-fluoro-β-D-ribofuranosyl)adenine 
• 98-88-4 benzoyl chloride 
• 151725-87-0 9-(5-O-tert-butyldimethylsilyl-2,3-dideoxy-3-fluoro-β-D-erythro-pentofuranosyl)adenine 

Downstream Products

• 210689-32-0 Benzoic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-{(2-chloro-phenoxy)-[(2R,3S,5R)-5-(6-dibenzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethoxy]-phosphoryloxy}-2-hydroxymethyl-tetrahydro-furan-3-yl ester 

Relevant academic research and scientific papers

Synthesis and biological activity of modified (2'-5')triadenylates containing 2'-terminal 2',3'-dideoxy-3'-fluoroadenosine derivatives

Some new (2'-5')triadenylates 13-16, containing at the 2'-terminal end 3'-fluoro-2',3'-dideoxyadenosine derivatives, have been synthesized by the phosphotriester method. The selectively blocked nucleosides 2, 4, 5, and 7 were synthesized from the corresponding unprotected 'nucleosides 1, 3, and 6. The synthesized trimers 13 and 14 were 4- and 8-fold, respectively, more stable towards phosphodiesterase from Crotalus durissus than the natural trimer 17. In comparison to trimer 17 the new compounds 13-15 inhibit HIV-1 reverse transcriptase (RT) activity, and 15 and 16 the HIV-1 induced syncytia formation 2-3 fold whereas none of 13-16 can improve RNase L activity.

Synthetic Approaches towards Nucleocidin and Selected Analogues; anti-HIV Activity in 4'-Fluorinated Nucleoside Derivatives

Nucleocidin 1 has been synthesised from the adenosine derivative 4 via the intermediacy of the dihalogeno compound 9.The latter compound showed slight but significant activity against HIV-infected cells while the isomer 10 and the monohalogeno compound 60 were inactive.Synthetic approaches towards other 4'-fluorinated nucleoside derivatives are also described.The epimeric 4'-fluorinated nucleosides 26 and 27 displayed similar activity against HIV-infected cells to that observed for the dihalogenated compound 9.