210760-39-7

Basic information

• Product Name: 3-Benzoyl-5-fluoro-1-(2-trityloxy-1-trityloxymethyl-ethyl)-1H-pyrimidine-2,4-dione
• CAS NO: 210760-39-7
• Molecular Weight: 792.906
• Mol File: 210760-39-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Benzoyl-5-fluoro-1-(2-trityloxy-1-trityloxymethyl-ethyl)-1H-pyrimidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Benzoyl-5-fluoro-1-(2-trityloxy-1-trityloxymethyl-ethyl)-1H-pyrimidine-2,4-dione(210760-39-7)
• EPA Substance Registry System: 3-Benzoyl-5-fluoro-1-(2-trityloxy-1-trityloxymethyl-ethyl)-1H-pyrimidine-2,4-dione(210760-39-7)

Safety Data

• Hazardous Substances Data: 210760-39-7(Hazardous Substances Data)

Upstream product

• 5443-10-7 1,3-bis (trityloxy)propan-2-ol 
• 61251-77-2 3-benzoyl-5-fluorouracil 

Downstream Products

• 1026549-15-4 Benzoic acid 5-(5-fluoro-2-oxo-4-[1,2,4]triazol-1-yl-2H-pyrimidin-1-yl)-[1,3]dioxan-2-ylmethyl ester 

Relevant articles and documents

Ring-expanded nucleoside analogues. 1,3-Dioxan-5-yl pyrimidines

1,3-Dioxan-5-yl pyrimidine nucleoside analogues, higher homologues of antiviral and anticancer 1,3-dioxolanes, were prepared from bis-1,3- tritylglycerol and 3-benzoylated bases (uracil, 5-fluorouracil, thymine). Mitsunobu condensation, deprotection, and cycloacetalization gave cis/trans mixtures of 2,5-disubstituted-1,3-dioxanes in which the desired cis stereoisomers predominated. Cytosine derivatives could not be obtained in this manner; N4-benzoylcytosine afforded an O-2 alkylated Mitsunobu product that rearranged to an O2-(2,3-dihydroxypropyl)cytosine on detritylation with aqueous acetic acid. Cytosine and 5-fluorocytosine nucleosides were therefore prepared from the corresponding uracils via their 1,2-4-triazole derivatives. 1H NMR data established the conformational preference for equatorial 2'- hydroxymethyl and axial 5'-base in the cis isomers; the trans compounds were diequatorial. Despite their conformations, the cis nucleosides showed no antiviral activity.