210826-67-8

Basic information

• Product Name: 1-(3-Bromophenyl)-cyclobutanol
• Synonyms: 1-(3-Bromophenyl)-cyclobutanol;1-(3-BROMOPHENYL)CYCLOBUTAN-1-OL
• CAS NO: 210826-67-8
• Molecular Formula: C10H11BrO
• Molecular Weight: 227.09774
• Mol File: 210826-67-8.mol

Chemical Properties

• Boiling Point: 318.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.547±0.06 g/cm3(Predicted)
• PKA: 14.41±0.20(Predicted)
• CAS DataBase Reference: 1-(3-Bromophenyl)-cyclobutanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Bromophenyl)-cyclobutanol(210826-67-8)
• EPA Substance Registry System: 1-(3-Bromophenyl)-cyclobutanol(210826-67-8)

Safety Data

• Hazardous Substances Data: 210826-67-8(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-(3-Bromophenyl)-cyclobutanol is used as a key intermediate for the synthesis of various pharmaceutical compounds and organic molecules. Its presence of a bromine atom and cyclobutanol ring allows for further functionalization and the creation of a diverse range of molecules with potential applications in different industries.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1-(3-Bromophenyl)-cyclobutanol is utilized as a valuable tool for drug discovery and development. Its unique structure may contribute to the design of novel therapeutic agents, and its potential pharmacological properties make it a promising candidate for further investigation and optimization.
Used in Pharmaceutical Industry:
1-(3-Bromophenyl)-cyclobutanol is used as a building block for the development of new drugs in the pharmaceutical industry. Its structural features facilitate the creation of molecules with specific biological targets, potentially leading to the discovery of innovative treatments for various diseases and conditions.

Upstream product

• 1191-95-3 cyclobutanone 
• 108-36-1 1,3-dibromobenzene 

Downstream Products

• 374589-00-1 5-(3-bromophenyl)-3,4-dihydro-2H-pyrrole 
• 17789-13-8 1-bromo-3-cyclobutylbenzene 

Relevant articles and documents

Iron-Catalyzed Ring Expansion of Cyclobutanols for the Synthesis of 1-Pyrrolines by Using MsONH3OTf

The synthesis of 1-pyrrolines from cyclobutanol derivatives and an aminating reagent (MsONH3OTf) has been developed. This one-pot procedure achieves C–N bond/C═N bond formation via ring expansion. A series of 1-pyrroline derivatives are synthes

AZASPIROCYCLES AS MONOACYLGLYCEROL LIPASE MODULATORS

Azaspirocycle compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, bipolar disorder), cancers and eye conditions: wherein X, R1, R2a, R2b, R3, m, n, o, and p are defined herein.

Generation of bromophenyllithium reagents from dibromobenzenes and addition to carbonyl and nitrile electrophiles

An evaluation of the mono-lithiation of all three regioisomers of dibromobenzene using n-butylithium was performed. The resulting aryllithium reagents were added to electrophiles such as ketones, aldehydes, nitriles and amides to afford the desired benzylic alcohols or ketones.