21086-49-7

Usage

Uses

Used in Agricultural Industry:
(4-chloro-2-nitrophenoxy)acetic acid is used as a herbicide for controlling the growth of weeds and unwanted vegetation. Its application reason is that it mimics the action of the natural plant hormone auxin, disrupting the normal growth and development of plants and leading to their eventual death.
Used in Research and Development:
(4-chloro-2-nitrophenoxy)acetic acid is used as a research tool for studying plant growth and development. Its application reason is that it provides insights into the effects of plant hormones and their role in the growth and development of plants, aiding in the development of new strategies for plant management and crop production.

InChI:InChI=1/C8H6ClNO5/c9-5-1-2-7(15-4-8(11)12)6(3-5)10(13)14/h1-3H,4H2,(H,11,12)

Upstream product

• 122-88-3 4-Chlorophenoxyacetic acid 
• 89-64-5 p-chloro-o-nitrophenol 
• 344443-67-0 ethyl 4-chloro-2-nitrophenoxyacetate 
• 79-11-8 chloroacetic acid 

Downstream Products

• 1299293-54-1 O,O-dimethyl α-(4-chloro-2-nitrophenoxyacetoxy)ethylphosphonate 
• 75263-82-0 C₈H₅Cl₂NO₄ 
• 1246788-15-7 C₂₀H₁₃Cl₂N₃O₄ 
• 1341199-23-2 N-[4-(aminosulfonyl)-2-methylphenyl]-2-(4-chloro-2-nitrophenoxy)acetamide 
• 1341199-24-3 N-[4-(aminosulfonyl)-2-methylphenyl]-2-(4-chloro-2-aminophenoxy)acetamide 
• 1416363-86-4 C₂₂H₂₀ClN₃O₅S 
• 1416363-87-5 C₂₃H₂₂ClN₃O₅S 
• 1416363-88-6 C₂₃H₂₂ClN₃O₅S 
• 1416363-89-7 C₂₃H₂₂ClN₃O₅S 
• 1416363-90-0 C₂₂H₁₉Cl₂N₃O₅S 
• 1416363-91-1 C₂₂H₁₉ClFN₃O₅S 
• 1416363-92-2 C₂₂H₁₉ClN₄O₇S 
• 1416363-93-3 C₂₂H₁₉ClN₄O₇S 
• 1416363-94-4 C₂₃H₁₉ClF₃N₃O₅S 

Relevant academic research and scientific papers

Identification of the novel N-phenylbenzenesulfonamide derivatives as potent HIV inhibitors

Searching for more safe and effective agents for HIV treatments is still an urgent topic worldwide. Based on our continuous modifications on the benzophenone derivatives as HIV-1 reverse transcriptase (RT) inhibitors, a new template bearing N-phenylbenzenesulfonamide (PBSA) structure was designed to enhance the interactions with HIV-1 RT. In this manuscript, a series of PBSA derivatives were synthesized and evaluated for their anti-HIV-1 activity. The preliminary test showed that these compounds were potent to inhibit wild-type HIV-1 with EC50 values ranging of 0.105-14.531 μmol/L. In particular, compound 13f not only has high anti-HIV-1 activity (0.108 μmol/L), but also possesses low toxicity with a TI value of 1816.6. Furthermore, the major interactions of the inhibitor 13f with HIV-1 RT were also investigated using the molecular modelling. Our discovered structure-activity relationships (SARs) of these analogues may serve as an important clue for further optimizations.

Synthesis, structure-activity relationships, and docking studies of N-phenylarylformamide derivatives (PAFAs) as non-nucleoside HIV reverse transcriptase inhibitors

A series of N-phenylarylformamide derivatives (PAFAs) with anti-wild-type HIV-1 activity (EC50 values) ranging from 0.3 nM to 5.1 nM and therapeutic index (TI) ranging from 10 616 to 271 000 were identified as novel non-nucleoside reverse trans

Studies of O,O-Dimethyl α-(2,4-Dichlorophenoxyacetoxy) ethylphosphonate (HW02) as a new herbicide. 1. Synthesis and herbicidal activity of HW02 and analogues as novel inhibitors of pyruvate dehydrogenase complex

On the basis of the previous work for optimization of O,O-diethyl α-(substituted phenoxyacetoxy)alkylphosphonates, further extensive syntheticmodifications were made to the substituents in alkylphosphonate and phenoxymoieties of the title compounds. New O,O-dimethyl α-(substituted phenoxyacetoxy)alkylphosphonates were synthesized as potential inhibitors of pyruvate dehydorogenase complex (PDHc). Their herbicidal activity and efficacy in vitro against PDHc were examined. Some of these compounds exhibited significant herbicidal activity and were demonstrated to be effective inhibitors of PDHc from three different plants. The structure-activity relationships of these compounds including previously reported analogous compoundswere studied by examining their herbicidal activities. Both inhibitory potency against PDHc and herbicidal activity of title compounds could be increased greatly by optimizing substituent groups of the title compounds. O,O-Dimethyl α-(2,4- dichlorophenoxyacetoxy)ethylphosphonate (I-5), which acted as a competitive inhibitor of PDHc with much higher inhibitory potency against PDHc from Pisum sativum and Phaseolus radiatus than from Oryza sativa, was found to be themost effective compound against broadleaf weeds and showed potential utility as herbicide.

ipso Nitration in p-halophenyl ethers

Addition of nitronium ion ipso to halogen occurs on nitration of the p-haloanisoles in acetic anhydride at -60 deg C.In the cases of p-fluoro- and p-chloro-anisole, addition of the nitronium ion is reversible and only small amounts of ipso products are obtained.With p-bromoanisole nitrodebromination occurs.When p-halophenyl ethers containing a trapping substituent, e.g., 2-(4-chlorophenoxy)-2-methylpropanoic acid, are used as substrates, substantial amounts of the spiro diene with nitro ipso to halogen, e.g., 3,3-dimethyl-8-chloro-8-nitro-1,4-dioxaspirodeca-6,9-dien-2-one, can be isolated.The results demonstrate that extensive ipso attack at the halogen-substituted position is general in the nitration of p-halophenyl ethers.Key words: ipso nitration, ether, diene, p-haloanisole.