75263-82-0

Upstream product

• 21086-49-7 (4-chloro-2-nitro-phenoxy)-acetic acid 
• 89-64-5 p-chloro-o-nitrophenol 
• 344443-67-0 ethyl 4-chloro-2-nitrophenoxyacetate 

Downstream Products

• 1299293-54-1 O,O-dimethyl α-(4-chloro-2-nitrophenoxyacetoxy)ethylphosphonate 
• 1341199-24-3 N-[4-(aminosulfonyl)-2-methylphenyl]-2-(4-chloro-2-aminophenoxy)acetamide 
• 1416363-86-4 C₂₂H₂₀ClN₃O₅S 
• 1416363-87-5 C₂₃H₂₂ClN₃O₅S 
• 1416363-88-6 C₂₃H₂₂ClN₃O₅S 
• 1416363-89-7 C₂₃H₂₂ClN₃O₅S 
• 1416363-90-0 C₂₂H₁₉Cl₂N₃O₅S 
• 1416363-91-1 C₂₂H₁₉ClFN₃O₅S 
• 1416363-92-2 C₂₂H₁₉ClN₄O₇S 
• 1416363-93-3 C₂₂H₁₉ClN₄O₇S 
• 1416363-94-4 C₂₃H₁₉ClF₃N₃O₅S 
• 1416363-95-5 C₂₃H₂₂ClN₃O₆S 
• 1341199-21-0 C₂₄H₂₄ClN₃O₅S 
• 1341199-20-9 C₂₄H₂₄ClN₃O₅S 

Relevant academic research and scientific papers

Identification of the novel N-phenylbenzenesulfonamide derivatives as potent HIV inhibitors

Searching for more safe and effective agents for HIV treatments is still an urgent topic worldwide. Based on our continuous modifications on the benzophenone derivatives as HIV-1 reverse transcriptase (RT) inhibitors, a new template bearing N-phenylbenzenesulfonamide (PBSA) structure was designed to enhance the interactions with HIV-1 RT. In this manuscript, a series of PBSA derivatives were synthesized and evaluated for their anti-HIV-1 activity. The preliminary test showed that these compounds were potent to inhibit wild-type HIV-1 with EC50 values ranging of 0.105-14.531 μmol/L. In particular, compound 13f not only has high anti-HIV-1 activity (0.108 μmol/L), but also possesses low toxicity with a TI value of 1816.6. Furthermore, the major interactions of the inhibitor 13f with HIV-1 RT were also investigated using the molecular modelling. Our discovered structure-activity relationships (SARs) of these analogues may serve as an important clue for further optimizations.

Synthesis, structure-activity relationships, and docking studies of N-phenylarylformamide derivatives (PAFAs) as non-nucleoside HIV reverse transcriptase inhibitors

A series of N-phenylarylformamide derivatives (PAFAs) with anti-wild-type HIV-1 activity (EC50 values) ranging from 0.3 nM to 5.1 nM and therapeutic index (TI) ranging from 10 616 to 271 000 were identified as novel non-nucleoside reverse trans

Studies of O,O-Dimethyl α-(2,4-Dichlorophenoxyacetoxy) ethylphosphonate (HW02) as a new herbicide. 1. Synthesis and herbicidal activity of HW02 and analogues as novel inhibitors of pyruvate dehydrogenase complex

On the basis of the previous work for optimization of O,O-diethyl α-(substituted phenoxyacetoxy)alkylphosphonates, further extensive syntheticmodifications were made to the substituents in alkylphosphonate and phenoxymoieties of the title compounds. New O,O-dimethyl α-(substituted phenoxyacetoxy)alkylphosphonates were synthesized as potential inhibitors of pyruvate dehydorogenase complex (PDHc). Their herbicidal activity and efficacy in vitro against PDHc were examined. Some of these compounds exhibited significant herbicidal activity and were demonstrated to be effective inhibitors of PDHc from three different plants. The structure-activity relationships of these compounds including previously reported analogous compoundswere studied by examining their herbicidal activities. Both inhibitory potency against PDHc and herbicidal activity of title compounds could be increased greatly by optimizing substituent groups of the title compounds. O,O-Dimethyl α-(2,4- dichlorophenoxyacetoxy)ethylphosphonate (I-5), which acted as a competitive inhibitor of PDHc with much higher inhibitory potency against PDHc from Pisum sativum and Phaseolus radiatus than from Oryza sativa, was found to be themost effective compound against broadleaf weeds and showed potential utility as herbicide.