344443-67-0

Basic information

• Product Name: ethyl 2-(4-chloro-2-nitrophenoxy)acetate
• Synonyms: ethyl 2-(4-chloro-2-nitrophenoxy)acetate;2-(4-chloro-2-nitrophenoxy)acetic acid ethyl ester;2-(4-chloro-2-nitro-phenoxy)acetic acid ethyl ester;ethyl (4-chloro-2-nitrophenoxy)acetate;ethyl 2-(4-chloro-2-nitro-phenoxy)ethanoate;MFCD00858997
• CAS NO: 344443-67-0
• Molecular Formula: C₁₀H₁₀ClNO₅
• Molecular Weight: 259.65
• Mol File: 344443-67-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-(4-chloro-2-nitrophenoxy)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-chloro-2-nitrophenoxy)acetate(344443-67-0)
• EPA Substance Registry System: ethyl 2-(4-chloro-2-nitrophenoxy)acetate(344443-67-0)

Safety Data

• Hazardous Substances Data: 344443-67-0(Hazardous Substances Data)

Upstream product

• 89-64-5 p-chloro-o-nitrophenol 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 13212-63-0 6-chloro-4-hydroxy-(2H)-1,4-benzoxazin-3(4H)-one 
• 847148-63-4 (4-chloro-2-{[2-chloro-4-(ethylsulfonyl)phenyl]amino}phenoxy)acetic acid 
• 847148-13-4 [4-chloro-2-[[4-(methylsulfonyl)phenyl]amino]phenoxy]-acetic acid 
• 21086-49-7 (4-chloro-2-nitro-phenoxy)-acetic acid 
• 75263-82-0 C₈H₅Cl₂NO₄ 
• 1416364-06-1 C₂₆H₂₂ClN₃O₅S 
• 1416364-05-0 C₂₆H₂₂ClN₃O₅S 
• 1416364-04-9 C₂₃H₂₀Cl₃N₃O₅S 
• 1416364-03-8 C₂₄H₂₂ClN₃O₅S 
• 1416364-02-7 C₂₃H₁₈Cl₂N₄O₅S 
• 1416364-01-6 C₂₂H₁₈Br₂ClN₃O₅S 
• 1416364-00-5 C₂₂H₁₈BrCl₂N₃O₅S 
• 1416363-99-9 C₂₂H₁₈Cl₃N₃O₅S 
• 1341199-22-1 C₂₂H₁₈Cl₃N₃O₅S 

Relevant articles and documents

Identification of the novel N-phenylbenzenesulfonamide derivatives as potent HIV inhibitors

Searching for more safe and effective agents for HIV treatments is still an urgent topic worldwide. Based on our continuous modifications on the benzophenone derivatives as HIV-1 reverse transcriptase (RT) inhibitors, a new template bearing N-phenylbenzenesulfonamide (PBSA) structure was designed to enhance the interactions with HIV-1 RT. In this manuscript, a series of PBSA derivatives were synthesized and evaluated for their anti-HIV-1 activity. The preliminary test showed that these compounds were potent to inhibit wild-type HIV-1 with EC50 values ranging of 0.105-14.531 μmol/L. In particular, compound 13f not only has high anti-HIV-1 activity (0.108 μmol/L), but also possesses low toxicity with a TI value of 1816.6. Furthermore, the major interactions of the inhibitor 13f with HIV-1 RT were also investigated using the molecular modelling. Our discovered structure-activity relationships (SARs) of these analogues may serve as an important clue for further optimizations.

Combined strategy for phytotoxicity enhancement of benzoxazinones

Fifteen new derivatives of D-DIBOA, including aromatic ring modifications and the addition of side chains in positions C-2 and N-4, were synthesized and their phototoxicity, selectivity, and structure-activity relationships evaluated. The most active comp

PHENOXIACETIC ACID DERIVATIVES

The invention relates to certain 2-substituted phenoxyacetic acid derivatives of formula (I), in which the variables are as defined in the claims, useful in the treatment of diseases or conditions in which modulation of the CRTh2 receptor is beneficial, s