21093-51-6

Usage

Uses

W-84 Dibromide is a potent allosteric modulator of muscarinic receptors.

Biological Activity

Stabilizes cholinergic antagonist-receptor complexes by an allosteric effect. Thus increases the protective effect of atropine against organophosphate poisoning.

Upstream product

• 109-55-7 1-amino-3-(dimethylamino)propane 
• 85-44-9 phthalic anhydride 
• 629-03-8 1 ,6-dibromohexane 
• 13474-65-2 N,N-dimethyl-N-(3-phthalimidopropyl)amine 

Downstream Products

• 88-99-3 benzene-1,2-dicarboxylic acid 

Relevant academic research and scientific papers

Elevation of ligand binding to muscarinic M2 acetylcholine receptors by bis(ammonio)alkane-type allosteric modulators

Bis(ammonio)alkane-type compounds are archetypal muscarinic allosteric modulators. Phthalimido-substituted hexane-bis-ammonium agents were methylated in the phthalimide moieties and the lateral propyl side chains. All compounds retarded allosterically the dissociation of the orthosteric ligand [3H]N-methylscopolamine ([3H]NMS) from porcine heart M2 receptors. [3H]NMS equilibrium binding was reduced, left unaltered, or elevated, depending on the degree and position of methylation. This is the first time that an allosteric elevation of ligand binding is demonstrated for bis(ammonio)alkane-type compounds.

Real time observation of microwave-enhanced reactions via fast FTIR spectroscopy

Microwave-enhanced reactions are very fast in comparison to thermal reactions. The determination of optimal end point often fails because conventional analytical methods are too slow. Therefore, we established a fast method using FTIR spectroscopy. The re

A fast and efficient track to allosteric modulators of muscarinic receptors: Microwave-assisted syntheses

By using microwave irradiation bisammonium-and bispyridinium-type allosteric modulators of muscarinic receptors can be obtained fast and efficiently.