211053-75-7

Upstream product

• 100-52-7 benzaldehyde 
• 59633-91-9 rac-12-nor-drimane-8α,11-diol 
• 190388-66-0 (-)-(1S,2R,4aS,8aS)-2-hydroxy-decahydro-5,5,8a-trimethyl-1-naphthylmethanol 
• 211053-74-6 [(3S,4aR,6aS,10aS,10bS)-decahydro-7,7,10a-trimethyl-1H-naphtho[2,1-d][1,3]dioxin-3-yl]benzene 

Downstream Products

• 211053-77-9 Acetic acid (1S,2R,4aS,8aS)-2-benzyloxy-5,5,8a-trimethyl-decahydro-naphthalen-1-ylmethyl ester 
• 211053-79-1 (-)-(1R,2S,4aS,8aS)-2-benzyloxy-1-bromomethyl-decahydro-5,5,8a-trimethylnaphthalene 
• 6790-58-5 (-)-ambroxide 

Relevant academic research and scientific papers

Total synthesis of (+)-galanolactone

Regioselective monobenzylation of the chemoenzymatically prepared chiral decalin-type diol ((8aS)-6) via the benzylidene acetal ((8aS)-11) afforded the primary alcohol ((8aS)-7), from which total synthesis of (+)-galanolactone (1) was achieved and formal syntheses of (+)-(E)-8β(17), 12-labddiene-15, 16-dial ((+)-3) and (+)-coronarin E (4) were carried out.

Synthesis of decalin type chiral synthons based on enzymatic functionalisation and their application to the synthesis of (-)-ambrox and (+)-zonarol

Stereoselective syntheses of (-)-ambrox 2 and (+)-zonarol 3 were achieved based on the enzymatic syntheses of (8aS)- and (8aR)-decalin-type 1,3-diols 1, respectively. Non-racemic intermediates such as (8aS)-1 and (8aR)-1 were obtained based on the enantioselective hydrolyses of the phenolic acetal derivative (±)-7 by acylase I.