211100-71-9Relevant academic research and scientific papers
Synthesis and biological activity of an optically pure 10-spirocyclopropyl analog of huperzine A
Kozikowski, Alan P.,Prakash,Saxena, Ashima,Doctor, Bhupendra P.
, p. 1287 - 1288 (2007/10/03)
The synthesis of a spirocyclic analog of huperzine A that bears a cyclopropane ring at its 10-position has been carried out in an enantioselective manner using a diastereoselective Michael-aldol reaction; in assays of AChE inhibition, this compound was found to be nearly as active as huperzine A itself, with comparable on and off rates from the enzyme.
