211134-54-2Relevant academic research and scientific papers
Chiral symmetric phosphoric acid esters as sources of optically active organophosphorus compounds
Kolodiazhnyi, Oleg I.,Grishkun, Evgen V.,Sheiko, Serge,Demchuk, Oleg,Thoennessen, Holger,Jones, Peter G.,Schmutzler, Reinhard
, p. 1645 - 1649 (1998)
Chiral symmetric di- and trialkylphosphites, derivatives of (-)-borneol, (-)-menthol and (-)-1,2:5,6-di-Oisopropylidene-α-D-glucofuranose, were studied as starting reagents for the preparation of chiral organophosphorus compounds. The reaction occurs by a
Asymmetric synthesis of α-substituted alkylphosphonates based on symmetrical dialkyl phosphites
Kolodiazhnyi,Grishkun,Sheiko,Demchuk,Thoennessen,Jones,Schmutzler
, p. 1568 - 1573 (2007/10/03)
Chiral C2-symmetrical dialkyl phosphites and C3-symmetrical trialkyl phosphites, derived from (-)-borneol, (-)-menthol, and 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose, were studied as the starting reagents for the preparation of chiral organophosphorus compounds. The reactions of C2-symmetrical dialkyl phosphites and C3-symmetrical trialkyl phosphites with aldehydes and amines or aldehydes are accompanied by asymmetrical induction at the α-carbon atom to yield optically active α-aminoalkylphosphonates or α-hydroxyalkylphosphonates, respectively. The stereoselectivity of the reaction depends on the structure of the starting compounds and the reaction conditions.
