211173-45-4Relevant academic research and scientific papers
Nickel-catalyzed allylic substitution of simple alkenes
Matsubara, Ryosuke,Jamison, Timothy F.
, p. 1860 - 1875 (2011)
This report describes a nickel-catalyzed allylic substitution process of simple alkenes whereby an important structural motif, a 1,4-diene, was prepared. The key to success is the use of an appropriate nickel-phosphine complex and a stoichiometric amount of silyl triflate. Reactions of 1-alkyl-substituted alkenes consistently provided 1,1-disubstituted alkenes with high selectivity. Insight into the reaction mechanism as well as miscellaneous application of the developed catalytic process is also documented.
