2113-89-5

Upstream product

• 62973-00-6 2-(3-oxo-butyrylamino)-3-phenylpropionic acid methyl ester 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 17667-57-1 (S)-N-acetoacetyl-phenylalanine ethyl ester 

Downstream Products

• 129029-32-9 (4S,5S)-5-Benzyl-2-oxo-4-hydroxypyrrolidine 
• 129029-33-0 (4R,5S)-5-Benzyl-4-hydroxy-2-oxopyrrolidine 
• 76562-78-2 5-benzyl-3-(1-iminoethyl)tetramic acid 
• 128892-65-9 (S)-5-Benzyl-4-hydroxy-1,5-dihydro-pyrrol-2-one 

Relevant academic research and scientific papers

A TECHNIQUE FOR MODIFICATION OF A BIO-PRODUCT MOLECULE AND APPLICATION OF WEED CONTROL

A series of herbicidal molecules derived from 3-acetyl-4-hydroxy-5-sec-butylpyrroline-2-ketone, a natural substance, and their potential use in agriculture for weed control. Through the modification of the 5-sec-butyl hydrocarbon chain and 3-acetyl group and the analysis of their biological functioning, newly designed molecules are superior to the original compound in herbicidal activity. These molecules inhibit the photosynthesis of the plants. The treated plants show significant damage in 24 hours and die within 3-5 days after the chemical treatment. In addition, the new molecule has relatively simple structure, they are easy to make and they have better physical properties. They are broad-spectrum, high potency herbicides.

Tetramic Acid Chemistry. Part 1. Reinvestigation of Racemisation during the Synthesis of Tetramic Acids via Dieckmann Cyclisation

Epimerisation during the synthesis of tetramic acids by Dieckmann cyclisation of the corresponding chiral N-acyl-α-amino esters was investigated.In the case of the isoleucine derivative, the extent of epimerisation was directly evaluated by 1H NMR analysis of the 3-acylated tetramic acids (3a,b) and (5a).A chemical correlation was carried out in the case of the 5-benzyl derivative (8h).The moderate overall yield and the partial epimerisation at position C-5 limit the usefulness of this approach for tetramic acid preparation.

12. Approaches to the Synthesis of Cytochalasans. Part 2. Pyrrolinone Derivatives as Basic Units

Several attempts to prepare 3-acetyl-5-benzyl-3-pyrrolin-2-one (7) from phenylalanine are described.This goal was only reached formally, because compound 7 exists in the tautomeric form of (Z)-5-benzyl-3-(1'-hydroxyethylidene)-4-pyrrolin-2-one (17) according to the spectral data.The problem of tautomerism in pyrrolinone systems is discussed.