211308-49-5Relevant academic research and scientific papers
COVALENT RAS INHIBITORS AND USES THEREOF
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, (2021/06/04)
The disclosure features compounds, or pharmaceutically acceptable salts thereof, alone and in combination with other therapeutic agents, pharmaceutical compositions, and protein conjugates thereof, capable of modulating biological processes including Ras, and their uses in the treatment of cancers.
RAS INHIBITORS
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, (2021/05/07)
The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
A general asymmetric synthesis of syn- and anti-beta-substituted cysteine and serine derivatives.
Xiong, Chiyi,Wang, Wei,Hruby, Victor J
, p. 3514 - 3517 (2007/10/03)
A stereodivergent synthetic route has been developed to make the optically pure anti- and syn-beta-substituted cysteine and serine derivatives. In this approach, the key intermediates, > 94% enantiomerically pure cyclic sulfates 3 and aziridines 7, were prepared from alpha,beta-unsaturated esters 1, employing the Sharpless asymmetric dihydroxylation. The high regio- and stereoselective ring-opening reactions of cyclic sulfates and aziridines provided enantiomerically pure beta-substituted cysteine and serine derivatives.
Synthesis of the antibiotically active part of agrocin 84
Filippov, Dmitri,Timmers, Cornelis M.,Roerdink, Aaron R.,Van Der Marel, Gijs A.,Van Boom, Jacques H.
, p. 4891 - 4894 (2007/10/03)
Phosphitylation of bis-O-silylated threo-2,3-dihydroxy-4- methylpentanamide and condensation of the resulting N-acylphosphorodiamidite with 2'-O-acetyl-3'-deoxyarabinoadenosine led, after oxidation and deprotection, to the isolation of the title compound.
