131401-46-2

Basic information

• Product Name: (E)-4-methyl-pent-2-enoic acid benzyl ester
• Synonyms: (E)-4-methyl-pent-2-enoic acid benzyl ester
• CAS NO: 131401-46-2
• Molecular Weight: 204.269
• Mol File: 131401-46-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (E)-4-methyl-pent-2-enoic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-methyl-pent-2-enoic acid benzyl ester(131401-46-2)
• EPA Substance Registry System: (E)-4-methyl-pent-2-enoic acid benzyl ester(131401-46-2)

Safety Data

• Hazardous Substances Data: 131401-46-2(Hazardous Substances Data)

Upstream product

• 39027-95-7 9H-carbazole-9-carbaldehyde 
• 7396-44-3 benzyl diethylphosphonoacetate 
• 1068-55-9 isopropylmagnesium chloride 
• 77509-00-3 phenylmethyl 4-methylpentanoate 
• 78-84-2 isobutyraldehyde 
• 5437-45-6 Benzyl bromoacetate 
• 1775-44-6 (2E)-4-methylpent-2-enoic acid 
• 100-39-0 benzyl bromide 
• 100-51-6 benzyl alcohol 
• 646-07-1 4-Methylpentanoic acid 

Downstream Products

• 211308-49-5 benzyl (2S,3R)-2,3-dihydroxy-4-methylpentanoate 
• 887703-72-2 1-(4-fluoro-phenyl)-4-isopropyl-4,5-dihydro-1H-pyrazole-3,5-dicarboxylic acid 5-benzyl ester 3-methyl ester 
• 330944-31-5 (4-methyl)-3-pentenyl (S)-2-[(1,1-dimethylethyl)diphenylsilyl]oxypropanoate 
• 330944-29-1 (1S)-1-[(4-methyl)pent-3-enyloxycarbonyl]ethyl 3-oxocyclohex-1-enecarboxylate 
• 330944-30-4 benzyl 4-methyl-3-pentenoate 
• 131401-50-8 Benzyl 2-Hydroxyimino-4-methylpentanoate 
• 428512-42-9 benzyl (4R,5S)-5-isopropyl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide 

Relevant articles and documents

COVALENT RAS INHIBITORS AND USES THEREOF

The disclosure features compounds, or pharmaceutically acceptable salts thereof, alone and in combination with other therapeutic agents, pharmaceutical compositions, and protein conjugates thereof, capable of modulating biological processes including Ras, and their uses in the treatment of cancers.

Stereoseleetive synthesis of polysubstituted alkenes through a phosphine-mediated three-component system of aldehydes, α-halo carbonyl compounds, and terminal alkenes

A study was conducted to demonstrate stereoselective synthesis of polysubstituted alkenes through a phosphine-mediated three-component system of aldehydes, α-halo carbonyl compounds, and terminal alkenes. Triphenylphosphine, α-halo carbonyl compounds, and methyl acrylate were added to a solution of aldehyde in chloroform or 1-propanol under nitrogen at room temperature. The resulting mixture was stirred at the specified temperature until transformation was completely observed by thin layer chromatography (TLC) analysis. The mixture was cooled to room temperature and purified by column chromatography on silica gel, eluting with petroleum ether/ethyl acetate. The study demonstrated that the first one-pot and three-component reaction of aldehydes, α-haloacetates, and terminal alkenes was developed in the presence of phenylphosphine to produce a wide range of trisubstituted alkenes with significant stereoselectivity.

Novel pyrazole-based HMG CoA reductase inhibitors

Novel compounds and pharmaceutical compositions useful as hypocholesterolemic and hypolipidemic agents are described. More specifically, potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (“HMG CoA reductase”) are described. Methods of using such compounds and compositions to treat subjects, including humans, suffering from hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, Alzheimer's Disease, benign prostatic hypertrophy (BPH), diabetes and osteoporosis are also described.