21134-02-1Relevant academic research and scientific papers
Mevalonic acid analogs as inhibitors of cholesterol biosynthesis
DeBold,Elwood
, p. 1007 - 1010 (1981)
A series of 20 mevalonic acid analogs were synthesized and tested for their ability to inhibit cholesterol biosynthesis from [2-14C]-mevalonate in rat liver homogenates. Removal of the 5-hydroxyl group from mevalonic acid produced an active inhibitor, 3-hydroxy-3-methylpentanoic acid. Removal of the 3-hydroxyl group, addition of an aromatic group in the 3-position, or insertion of a double bond reduced inhibitory activity. Compounds with an aromatic group or halide on the 5-position were active inhibitors. The most active inhibitor was 5-phenylpentanoic acid, with 50% inhibition at 0.064 mM.
Synthesis of a new homologous series of p-chlorophenyl alcohol amides, their anticonvulsant activity and their testing as potential GABA(B) receptor antagonists
Meza-Toledo, Sergio E.,Juarez-Carvajal, Enedina,Carvajal-Sandoval, Guillermo
, p. 797 - 801 (2007/10/03)
The anticonvulsant activity of a homologous series of p-chlorophenyl alcohol amides is described. The new compounds (±)-2-hydroxy-2-(4'-chlorophenyl)-butyramide (2), (±)-3-hydroxy-3-(4'-chlorophenyl)pentanamide (4) and (±)-4-hydroxy-4-(4'-chlorophenyl)-he
