211426-31-2

Basic information

• Product Name: (1R,4S)-2-[1-Phenyl-meth-(Z)-ylidene]-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester
• Synonyms: (1R,4S)-2-[1-Phenyl-meth-(Z)-ylidene]-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester
• CAS NO: 211426-31-2
• Molecular Weight: 285.386
• Mol File: 211426-31-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1R,4S)-2-[1-Phenyl-meth-(Z)-ylidene]-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,4S)-2-[1-Phenyl-meth-(Z)-ylidene]-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester(211426-31-2)
• EPA Substance Registry System: (1R,4S)-2-[1-Phenyl-meth-(Z)-ylidene]-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester(211426-31-2)

Safety Data

• Hazardous Substances Data: 211426-31-2(Hazardous Substances Data)

Upstream product

• 98-79-3 L-Pyroglutamic acid 
• 4931-66-2 methyl (S)-pyroglutamate 
• 211426-28-7 (S)-2-[1-(Imidazole-1-carbothioyloxy)-3-phenyl-prop-2-ynyl]-5-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 211426-27-6 (S)-2-(1-Hydroxy-3-phenyl-prop-2-ynyl)-5-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 211426-29-8 (S)-2-Methoxy-5-(3-phenyl-prop-2-ynyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 211426-26-5 (S)-2-Formyl-5-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 195964-54-6 1-tert-butyl 2-methyl (2S)-5-methoxypyrrolidine-1,2-dicarboxylate 
• 188200-05-7 1-(tertbutyloxycarbonyl)-5-(hydroxy)pyrrolidine-2-carboxylic acid methyl ester 
• 108963-96-8 (S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 211426-30-1 (S)-2-(3-Phenyl-prop-2-ynyl)-5-phenylsulfanyl-pyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 163513-98-2 (-)-(1R,4S)-tert-butyl 2-oxo-7-azabicyclo[2.2.1]heptane-7-carboxylate 

Relevant articles and documents

Formal synthesis of natural epibatidine and of its enantiomer: Use of radical cyclization in an enantiospecific route

(S)-Pyroglutamic acid was converted into the (phenylthio)acetylene 14, which undergoes radical cyclization to the 7-azabicyclo[2.2.1]heptane 15. Ozonolysis then affords ketone 4, a synthetic precursor of (-)-epibatidine.

A highly stereocontrolled asymmetric synthesis of the Taxol C-13 side chain; (4S, 5R)-2,4-Diphenyloxazoline-5 carboxylic acid

A stereoselective synthesis of (4S, 5R)-2,4-diphenyloxaline-5-carboxylic acid, a precursor of the Taxol C-13 side chain was achieved using palladium- catalyzed oxazoline formation reaction from commercially available amino acid.