211430-93-2Relevant academic research and scientific papers
A systematic study on the use of different organocatalytic activation modes for asymmetric conjugated addition reactions of isoindolinones
Scorzelli, Francesco,Di Mola, Antonia,De Piano, Francesco,Tedesco, Consiglia,Palombi, Laura,Filosa, Rosanna,Waser, Mario,Massa, Antonio
supporting information, p. 819 - 828 (2017/01/28)
In this article we describe a series of new asymmetric Michael reactions of carboxylate-3-substituted isoindolinones used as nucleophiles in the synthesis of valuable chiral tetrasubstituted derivatives. It has been shown that the reactivity and enantiose
Silver-catalyzed spirolactonization: first synthesis of spiroisoindole-γ-methylene-γ-butyrolactones
Rammah, Mohamed M.,Othman, Mohamed,Ciamala, Kabula,Strohmann, Carsten,Rammah, Mohamed B.
, p. 3505 - 3516 (2008/09/21)
γ-Acetylenic carboxylic acids are cyclized to spirolactones under mild conditions, in the presence of Ag2CO3 catalyst. The corresponding spiro-5-alkylidene-γ-butyrolactones were isolated in high yields, and this process constitutes an easy and efficient route to analogous structures of natural products of biological interest.
Halolactonization of γ-acetylenic acids: systhesis of novel spiroisoindole halobutyrolactones
Rammah, Mohamed M.,Othman, Mohamed,Msaddek, Moncef,Rammah, Mohamed B.
scheme or table, p. 1971 - 1981 (2009/04/06)
γ-Acetylenic carboxylic acids are cyclized to spirohalo butyrolactones, in the presence of NBS or NIS and K2CO3. The corresponding 5(E)-haloalkylidene-spirobutyrolactones were isolated in high yields, and this process constitutes an easy and efficient route to analogous structures of natural products of biological interest.
New fused lactones from indolizinediones via N-acyliminium ions
Othman, Mohamed,Pigeon, Pascal,Decroix, Bernard
, p. 8737 - 8744 (2007/10/03)
N-Arylmethylphthalimidine-3-carboxylates 3 are good precursors for the synthesis of ketones 5a,b or enols 6c-e which upon acidic treatment led to lactones 7 via an N-acyliminium ion.
