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211436-36-1

2-Bromo-5-ethyl-7-(4-methoxy-benzylamino)-10-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 211436-36-1 Structure

  • Basic information

    1. Product Name: 2-Bromo-5-ethyl-7-(4-methoxy-benzylamino)-10-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one
    2. Synonyms: 2-Bromo-5-ethyl-7-(4-methoxy-benzylamino)-10-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one
    3. CAS NO:211436-36-1
    4. Molecular Formula:
    5. Molecular Weight: 468.353
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 211436-36-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-Bromo-5-ethyl-7-(4-methoxy-benzylamino)-10-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-Bromo-5-ethyl-7-(4-methoxy-benzylamino)-10-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one(211436-36-1)
    11. EPA Substance Registry System: 2-Bromo-5-ethyl-7-(4-methoxy-benzylamino)-10-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one(211436-36-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 211436-36-1(Hazardous Substances Data)

211436-36-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 211436-36-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,1,4,3 and 6 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 211436-36:
(8*2)+(7*1)+(6*1)+(5*4)+(4*3)+(3*6)+(2*3)+(1*6)=91
91 % 10 = 1
So 211436-36-1 is a valid CAS Registry Number.

211436-36-1Downstream Products

211436-36-1Relevant articles and documents

Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 8. 8- Aryloxymethyl- and 8-arylthiomethyldipyridodiazepinones

Cywin, Charles L.,Klunder, Janice M.,Hoermann, MaryAnn,Brickwood, Janice R.,David, Eva,Grob, Peter M.,Schwartz, Racheline,Pauletti, Daniel,Barringer, Kevin J.,Shih, Cheng-Kon,Sorge, Christopher L.,Erickson, David A.,Joseph, David P.,Hattox, Susan E.

, p. 2972 - 2984 (1998)

Nevirapine (I) is the first human immunodeficiency virus type 1 (HIV-1) nonnucleoside reverse transcriptase (RT) inhibitor to reach regulatory approval. As a result of a second generation program around the tricyclic core system of nevirapine, 2-chloro-5,11-dihydro-11-ethyl-5-methyl-8-(2- (pyridin-4-yl)ethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (II)1a and 2-chloro-5,11dihydro-11-ethyl-5-methyl-8-phenylethyl-6H-dipyrido[3-2- b:2',3'-e][1,4]diazepin-6-one (III)1a were identified as broad spectrum HIV-1 RT inhibitors. A detailed examination of replacing either of the methylenes of the 8-ethyl linker of II or III is presented. It was found that 8-aryloxymethyl and 8-arylthiomethyl are the preferred pattern of substitution for potency against RT. The most potent compounds were further evaluated against a panel of clinically significant mutant RT enzymes (K103N, V106A, G190A, P236L) and in cytotoxicity and in vitro metabolism assays. The most potent compound was 2-chloro-8-phenylthiomethyl analogue 37 which displayed sub-100 nM activity against all HIV-1 RT enzymes tested.

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