21149-98-4

Usage

Uses

Used in Pharmaceutical Industry:
4-(1,1-dimethylethyl)-imidazole is used as an intermediate in the synthesis of various pharmaceuticals for its ability to facilitate the formation of desired chemical structures, enhancing the development of new drugs and improving the efficacy of existing ones.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(1,1-dimethylethyl)-imidazole is employed as an intermediate in the production of agrochemicals, contributing to the development of more effective and safer pesticides and other agricultural chemicals.
Used in Chemical Catalysts:
4-(1,1-dimethylethyl)-imidazole serves as a catalyst in various chemical reactions, promoting the formation of desired products and improving the efficiency of the synthesis processes.
Used in Chemical Stabilizers:
4-(1,1-diMethylethyl)-iMidazole is utilized as a stabilizer in the chemical industry to prevent unwanted side reactions and ensure the stability of the final products, thereby maintaining their quality and performance.
Used in Organic Compounds Synthesis:
4-(1,1-dimethylethyl)-imidazole is used as an intermediate in the synthesis of a wide range of organic compounds, including those with potential applications in various industries such as plastics, coatings, and dyes. Its presence in these compounds can enhance their properties and performance.

Upstream product

• 75-97-8 3,3-dimethyl-butan-2-one 
• 630-18-2 tert-butyl isocyanide 
• 30718-17-3 trimethylsilylmethyl isocyanide 
• 131043-87-3 (4S,5S)-5-tert-Butyl-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole 
• 77287-34-4 formamide 
• 5469-26-1 1-Bromopinacolon 
• 3473-63-0 formamidine acetic acid 
• 630-19-3 pivalaldehyde 

Downstream Products

• 888497-54-9 4-(1,1-dimethylethyl)-1-(4-cyanophenyl)-1-methyl-1H-imidazolium iodide 
• 110589-24-7 {Fe(C₃H₃N₂C(CH₃)3)(C₇₄H₆₄N₁₂O₄)}*(CH₃)2CO 
• 888497-53-8 1-(4-cyanophenyl)-4-(1,1-dimethyethyl)-imidazole 

Relevant academic research and scientific papers

SUBSTITUTED IMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted imidazole carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat a medical disorder, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.

FARNESOID X RECEPTOR AGONISTS AND USES THEREOF

Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.

Preparation method of plinabulin intermediate imidazole formaldehyde compound

The invention discloses a preparation method of an imidazole formaldehyde compound. According to the preparation method, the operation danger level and the production cost are reduced by optimizing and improving a preparation route method, optimizing reaction conditions and improving a post-treatment and purification method; the requirement on the corrosion resistance grade of reaction container equipment is low, the operation safety is good, and the post-treatment is green and environment-friendly; and the preparation method has the advantages of simple operation of each step, safe and feasible solvent and process conditions, realization of environment-friendly production, and wide application prospect.

MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Modulators of Cystic Fibrosis Transmembrane Conductance Regulator

The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

GLUCAGON RECEPTOR MODULATORS

The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4, L, B1, B2, B3 and B4 are as defined herein. The compounds of Formula I have been found to act as glucagon antagonists or inverse agonists. Consequently, the compounds of Formula I and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucagon.

DISUBSTITUTED IMIDAZOLE DERIVATIVES AS MODULATORS OF RAF KINASE

Novel substituted imidazole compounds, compositions containing them, and methods of using them for the inhibition of Raf kinase activity are provided. The new compounds and compositions may be used either alone or in combination with an additional agent f

NOVEL HETEROARYL DERIVATIVE

A heteroaryl derivative of the formula (1): (wherein Ring Z is an optionally substituted heteroaryl, R1 is a carboxyl group or an alkoxycarbonyl group, etc., W1 and W2 are an optionally substituted lower alkylene, Ar1 is an optionally substituted arylene or an optionally substituted heteroarylene, W3 is a single bond, a lower alkylene, a lower alkenylene, etc., W4 is a single bond, -NR10-, etc., Ar2 is an optionally substituted aryl or an optionally substituted heteroaryl), or a prodrug thereof, or a pharmaceutically acceptable salt thereof.

Process for the synthesis of imidazoles

The present invention provides a process for the preparation of imidazoles by reacting a cyano compound with a silylalkylisocyanide compound. Such imidazoles are useful pharmacologically-active compounds and/or intermediates for the preparation of pharmacologically-active compounds.

(2S)-2-((PYRIMIDIN-4-YL)AMINO)-4-METHYLPENTANOIC ACID AMINOETHYLAMID DERIVATIVES AS IL-8 RECEPTOR MODULATORS FOR THE TREATMENT OF ATHEROSCLEROSIS AND RHEUMATOID ARTHRITIS

The invention relates to compounds of the formula: (I); wherein R1 is a basic moiety having the structure -NH(CH2)2NR5R6, (Formula II) or (Formula II); wherein R5, R6 and R7 are independently selected from H, (1-6C)alkyl, (2-6C)alken