21150-15-2

Usage

Type of compound

Organic compound

Functional group

Hydrazine functional group

Additional groups

Two benzoyl groups

Usage

Reagent in organic synthesis

Application

Building block in the production of pharmaceuticals and agrochemicals

Potential use

Treatment of cancer and other diseases

Known properties

Carcinogenic and mutagenic

Safety precautions

Proper handling and safety measures should be taken to minimize risk of exposure

Upstream product

• 1483-24-5 1-methyl-1-benzoylhydrazine 
• 93-97-0 benzoic acid anhydride 
• 60-34-4 methylhydrazine 
• 34413-60-0 N²-Methyl-N²-thiobenzoyl-benzhydrazid 
• 98-88-4 benzoyl chloride 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 7732-18-5 water 
• 725-12-2 2,5-bis-(phenyl)-1,3,4-oxadiazole 
• 1660-24-8 1-benzoyl-2-methylhydrazine 

Relevant academic research and scientific papers

Evidence of an nN(amide) → π*ArInteraction in N-Alkyl- N, N′-diacylhydrazines

1,2-Dibenzoyl-1-tert-butylhydrazine (RH-5849) and related N-alkyl-N,N′-diacylhydrazines are environmentally benign insect growth regulators. Herein, we show that an unusual nN(amide) → π*Ar interaction mediated by a hydrazide amide nitrogen atom plays a crucial role in stabilizing their biologically active trans-cis (t-c) rotameric conformations. We provide NMR and IR spectroscopic evidence for the presence of these interactions, which is also supported by X-ray crystallographic and computational studies.

1,3,4-Oxadiazolium-3-unsubstituted methanide 1,3-dipoles: useful synthons at -60 deg C: new synthesis of 1,2,3-trisubstituted and 1,2,3,4-tetrasubstituted pyrroles

1,3,4-Oxadiazolium-3-unsubstituted methanides have been trapped with substituted alkyne and alkene dipolarophiles at -60 deg C giving high yields of 2,3-di- and 2,3,4-trisubstituted 1-N-amidopyrroles from a cycloaddition rearrangement sequence.