1660-24-8

Upstream product

• 93-58-3 benzoic acid methyl ester 
• 60-34-4 methylhydrazine 
• 98-88-4 benzoyl chloride 
• 65-85-0 benzoic acid 
• 613-94-5 benzoic acid hydrazide 
• 77-78-1 dimethyl sulfate 
• 6327-62-4 N'-acetyl-N'-methylbenzohydrazide 

Downstream Products

• 57676-40-1 3-methyl-5-phenyl-2,3-dihydro-[1,3,4]oxadiazole 
• 51592-28-0 N'-Benzoyl-N-methyl-hydrazinecarbothioic acid O-methyl ester 
• 13281-47-5 1,4-Dibenzoyl-2-methylthiosemicarbazid 
• 80791-37-3 nonyl 3-benzoyl-2-methyldithiocarbazate 
• 1006-19-5 1-methyl-1,2-dihydro-3H-indazol-3-one 
• 77919-29-0 1-Benzoyl-2-methyl-4-phenylsemicarbazid 
• 774-65-2 benzoic acid tert-butyl ester 
• 879-60-7 3-methyl-5-phenyl-1,3,4-oxadiazol-2(3H)-one 
• 104637-74-3 2,5-Dimethyl-4-phenyl-2,5-dihydro-1,2,3,5-thiatriazol-1,1-dioxid 
• 104637-71-0 2-(α-Chlorphenylmethylen)-N,1-dimethyl-hydrazinsulfonamid 
• 59190-07-7 3-(2-methyl-5-phenyl-2H-[1,2,4]triazol-3-yl)-pyridine 
• 21150-15-2 N,N'-dibenzoyl-N-methyl-hydrazine 
• 51592-30-4 N'-Benzoyl-N-methyl-hydrazinecarbodithioic acid methyl ester 

Relevant academic research and scientific papers

Ruthenium-Catalyzed Three-Component Alkylation: A Tandem Approach to the Synthesis of Nonsymmetric N,N-Dialkyl Acyl Hydrazides with Alcohols

The borrowing hydrogen strategy has been applied in the synthesis of nonsymmetric N,N-dialkylated acyl hydrazides via a tandem three-component reaction catalyzed by a phosphine free diaminocyclopentadienone ruthenium tricarbonyl complex. This strategy represents the first direct one-pot approach to nonsymmetric functionalized acyl hydrazides. Different aromatic acyl hydrazides underwent dialkylation with a variety of primary or secondary alcohols and methanol or ethanol as alkylating agents in mild reaction conditions and good yields. Deuterium labelling experiments suggested that the primary or secondary alcohol was the hydrogen source in this tandem process. DFT calculations show that the combination of the tandem mixed product cannot be perfectly explained neither structurally nor electronically, but might be dependent of the physical state of the aldehyde or ketone intermediate (gaz vs. liquid) at the reaction temperature. (Figure presented.).

Evidence of an nN(amide) → π*ArInteraction in N-Alkyl- N, N′-diacylhydrazines

1,2-Dibenzoyl-1-tert-butylhydrazine (RH-5849) and related N-alkyl-N,N′-diacylhydrazines are environmentally benign insect growth regulators. Herein, we show that an unusual nN(amide) → π*Ar interaction mediated by a hydrazide amide nitrogen atom plays a crucial role in stabilizing their biologically active trans-cis (t-c) rotameric conformations. We provide NMR and IR spectroscopic evidence for the presence of these interactions, which is also supported by X-ray crystallographic and computational studies.

Conformational control ofN-methyl-N,N'-diacylhydrazines by noncovalent carbon bonding in solution

In recent years, some X-ray structural and computational evidence has emerged for noncovalent carbon bonding (C-bond). However, evidence of C-bonds in solution is limited. Herein, from the conformational analyses of strategically designedN-methyl-N,N'-dia

Synthesis of N′-propylhydrazide analogs of hydroxamic inhibitors of histone deacetylases (HDACs) and evaluation of their impact on activities of HDACs and replication of hepatitis C virus (HCV)

N′-Propylhydrazide analogs of hydroxamic inhibitors of histone deacetylases (HDACs), including tubastatin A, vorinostat and belinostat, were synthesized. All prepared compounds inhibited HDAC1/2/3, but not HDAC6, except for one hydrazide analog of HDAC4/5/7 inhibitor that was completely inactive. A novel 4-substituted derivative of N′-propylbenzohydrazide with extremely high anti-HCV activity was discovered.