211555-30-5

Usage

Uses

Used in Pharmaceutical Production:
2(1H)-Pyridinone, 6-amino-5-nitrois used as a building block in the synthesis of pharmaceuticals due to its unique chemical properties and reactivity. It contributes to the development of new drugs and medicines.
Used in Dye Manufacturing:
2(1H)-Pyridinone, 6-amino-5-nitrois utilized in the production of dyes, where its chemical structure imparts specific color characteristics to the dyes, making it valuable in the textile and other industries that require colorants.
Used in Organic Synthesis:
2(1H)-Pyridinone, 6-amino-5-nitroserves as an intermediate in organic synthesis, enabling the creation of a wide range of organic compounds for various applications across different industries.
Used in Chemical Research:
In the field of research, 2(1H)-Pyridinone, 6-amino-5-nitrois employed for studying chemical reactions and mechanisms, furthering scientific understanding and potentially leading to new discoveries and applications.

InChI:InChI=1/C5H5N3O3/c6-5-3(8(10)11)1-2-4(9)7-5/h1-2H,(H3,6,7,9)

Upstream product

• 27048-04-0 2-amino-6-chloro-3-nitropyridine 
• 4214-75-9 2-amino-3-nitropyridine 
• 385377-29-7 2-amino-3-nitropyridine 1-oxide 
• 2402-78-0 2,6-dichloropyridine 
• 16013-85-7 2,6-dicholoro-3-nitropyridine 
• 38533-61-8 2-chloro-6-methoxy-3-nitropyridine 
• 73896-36-3 6-methoxy-3-nitropyridin-2-amine 
• 5418-51-9 5-nitro-2-hydroxypyridine 

Downstream Products

• 642460-96-6 6-amino-3-iodo-5-nitro-1H-pyridin-2-one 
• 642460-97-7 6-amino-3-{3'-[(1,1-dimethylethyl)diphenylsilyloxy]-β-D-glycero-pentofuran-3'-ulos-1'-yl}-5-nitro-1H-pyridin-2-one 
• 883560-08-5 2-[4-(4-chloro-phenoxy)-phenyl]-3H-imidazo[4,5-b]pyridine-5-carbonitrile 
• 516481-68-8 5,6-diamino-pyridine-2-carbonitrile 
• 27048-04-0 2-amino-6-chloro-3-nitropyridine 

Relevant academic research and scientific papers

A 5 (4H)-pyridone combines furazane oxide synthesis method

The invention discloses a synthesis method of 4H-pyridofuroxan-5-one (III, also known as 4H, 5H-(1, 2, 5) oxadiazole (3, 4-b) pyridin-5-one-1-oxide). The synthesis method comprises the following steps (see the following reaction formula): enabling 2-amino-3-nitro-6-chloropyridine (I) to react with potassium (or sodium and the like) fluoride in a water-containing alcohol type solution, or enabling I to react with a nitrite in acetone to prepare 2-amino-3-nitro-6-hydroxypyridine (II); then performing oxidation and condensation reaction under alkaline conditions to prepare III. The synthesis process disclosed by the invention is simple and convenient to operate, and suitable for relatively large-scale production of III; a new way is provided for preparing anti-virus and anti-tumor compounds with the effect of releasing nitric oxide (NO).

Synthesis and properties of 5-cyano-substituted nucleoside analog with a donor-donor-acceptor hydrogen-bonding pattern

6-Aminopyridin-2-ones form Watson-Crick pairs with complementary purine analogues to add a third nucleobase pair to DNA and RNA, if an electron-withdrawing group at position 5 slows oxidation and epimerization. In previous work with a nucleoside analogue trivially named dZ, the electron withdrawing unit was a nitro group. Here, we describe an analogue of dZ (cyano-dZ) having a cyano group instead of a nitro group, including its synthesis, pKa, rates of acid-catalyzed epimerization, and enzymatic incorporation.

Non-standard nucleoside analogs with reduced epimerization

This invention relates to nucleoside, nucleotide, and oligonucleotide analogs that incorporate non-standard nucleobase analogs, defined to be those that present a pattern of hydrogen bonds to a paired nucleobase analog in a complementary strand that is different from the pattern presented by adenine, guanine, cytosine, and thymine. The invention is specifically concerned with compositions of matter that present the donor-donor-acceptor, donor-acceptor-donor, and acceptor-donor-donor non-standard hydrogen bonding patterns on pyrimidine analogs, where nucleoside analogs bearing these pyrimidine analogs do not epimerize as easily as those known in the art. The heterocycles on these nucleoside analogs are diaminopyridines and aminopyridones that have electron withdrawing groups attached to the position analogous to the 5-position of the ring in standard pyrimidines, including nitro, cyano, and carboxylic acid derivatives.

Methods for Chk2 inhibitor patient selection

The present invention contemplates a method to identify subjects that either have a tumor, or are at risk for tumor development, that are responsive to various inhibitors of an activated-Chk2 protein. Such Chk2 inhibitors may comprise a benzimidazole core structure, and derivatives thereof. Other Chk2 inhibitors may comprise nucleic acids, such as silencing interference RNA's specific for a Chk2 expression. Other Chk2 inhibitors may comprises proteins, such as antibodies. For example, the present invention contemplates that when a Chk2 inhibitor is administered during, or after, ionizing radiation tumor cell apoptosis is increased.

Novel non-benzimidazole chk2 kinase inhibitors

In a recent paper, [Arienti, K. L.; Brunmark, A.; Axe, F. U.; McClure, K. M.; Lee, A.; Blevitt, J.; Neff, D. K.; Huang, L.; Crawford, S.; Chennagiri, R. P.; Karlsson, L.; Brietenbucher, J. G. J. Med. Chem. 2005, 48, 1873], we described the discovery of a class of benzimidazole chk2 kinase inhibitors, exemplified by compound 1, which had radio-protective effects in human T-cells subjected to ionizing radiation. Here, a series of non-benzimidazole analogs intended to define the scope of the SAR about this new series of inhibitor, and allow for refinement of the binding model of these compounds to the chk2 kinase is described.

Expanding the Genetic Alphabet: Non-Epimerizing Nucleoside with the pyDDA Hydrogen-Bonding Pattern

6-Amino-3-(2′-deoxy-β-D-ribofuranosyl)-5-nitro-1H-pyridin-2-one (4), a C-glycoside exhibiting the nonstandard pyDDA hydrogen-bonding pattern, was synthesized via Heck coupling. The nitro group greatly enhances the stability of the nucleoside toward acid-c

Zinc-promoted direct amination of nitropyridines with methoxyamine via vicarious nucleophilic substitution

Direct animation of nitropyridines with methoxyamine in the presence of a stoichiometric amount of zinc(II) chloride under basic conditions proceeds to give aminonitropyridines.