2116-22-5 Usage
Description
Nadolol EP Impurity F is a compound related to Nadolol, which is a non-selective beta blocker used in the treatment of various cardiovascular conditions. As an impurity, it is likely to be found in the manufacturing process of Nadolol or in its pharmaceutical formulations. The presence of impurities in a drug can affect its efficacy, safety, and quality, making it essential to monitor and control their levels.
Uses
Used in Pharmaceutical Industry:
Nadolol EP Impurity F is used as a reference material for the identification and quantification of impurities in the manufacturing process of Nadolol. This helps ensure the quality, safety, and efficacy of the final drug product.
Used in Quality Control:
Nadolol EP Impurity F is used as a control substance in the quality control processes of pharmaceutical companies. It aids in the development and validation of analytical methods, such as high-performance liquid chromatography (HPLC) or other chromatographic techniques, to detect and quantify impurities in Nadolol formulations.
Used in Research and Development:
Nadolol EP Impurity F is used as a research tool in the development of new pharmaceutical products or the improvement of existing ones. It can help researchers understand the effects of impurities on the drug's performance and guide the optimization of manufacturing processes to minimize their presence.
Used in Regulatory Compliance:
Nadolol EP Impurity F is used by regulatory agencies and pharmaceutical companies to establish acceptable limits for impurities in Nadolol products. This ensures that the drug meets the required safety and efficacy standards and protects patients from potential adverse effects caused by impurities.
Check Digit Verification of cas no
The CAS Registry Mumber 2116-22-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,1 and 6 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 2116-22:
(6*2)+(5*1)+(4*1)+(3*6)+(2*2)+(1*2)=45
45 % 10 = 5
So 2116-22-5 is a valid CAS Registry Number.
2116-22-5Relevant articles and documents
Derivatives of 3,4-dihydro-1(2H)-naphthalenone as beta-adrenergic blocking agents. I. Bunolol and related analogs.
Schwender,Farber,Blaum,Shavel Jr.
, p. 684 - 688 (1970)
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A new route to amino-2-propanol structures with adrenergic β-blocker activity using low valent titanium
Bermudez,Del Campo,Sinisterra,Llama
, p. 4137 - 4140 (2007/10/03)
Amino-2-propanol structures can be obtained by addition to dibenzyl acetals of in situ generated dihalocarbenes using LTV (Low Valent Titanium). This methodology can be used to obtain adrenergic β-blockers with amino-2-propanol structure. Tetrahalomethane are the best dihalocarbene precursors. The yields obtained using halofluromethanes can be increased by addition of carbontetrachloride. A process that can imply halogen transfer may be proposed.
