711-82-0

Basic information

• Product Name: 2-(1-NAPHTHYLOXY) ETHANOL
• Synonyms: 2-(1-naphthalenyloxy)-ethano;2-(1-naphthalenyloxy)-Ethanol;2-(1-NAPHTHYLOXY) ETHANOL;2-naphthalen-1-yloxyethanol;2-(1-hydroxyethoxy) naphthalene;Ethanol,2-(1-naphthalenyloxy)-
• CAS NO: 711-82-0
• Molecular Formula: C₁₂H₁₂O₂
• Molecular Weight: 188.22
• Mol File: 711-82-0.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 355.2 °C at 760 mmHg
• Flash Point: 168.8 °C
• Appearance: /
• Density: 1.164 g/cm³
• Vapor Pressure: 1.16E-05mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(1-NAPHTHYLOXY) ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-NAPHTHYLOXY) ETHANOL(711-82-0)
• EPA Substance Registry System: 2-(1-NAPHTHYLOXY) ETHANOL(711-82-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 711-82-0(Hazardous Substances Data)

Usage

General Description

2-(1-Naphthyloxy) ethanol is a chemical compound with the molecular formula C12H12O2. It is a colorless liquid with a floral, waxy, and sweet odor, and is commonly used as a fragrance ingredient in cosmetics, perfumes, and personal care products. 2-(1-NAPHTHYLOXY) ETHANOL is also known for its calming and soothing properties and is used in aromatherapy and relaxation products. Additionally, it can be used as a solvent for organic materials and as a reagent in organic synthesis. It is important to handle this chemical with caution as it may cause eye and skin irritation, and it is recommended to use appropriate protective equipment when working with it.

InChI:InChI=1/C12H12O2/c13-8-9-14-12-7-3-5-10-4-1-2-6-11(10)12/h1-7,13H,8-9H2

Upstream product

• 75-21-8 oxirane 
• 90-15-3 α-naphthol 
• 107-21-1 ethylene glycol 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 90-11-9 1-Bromonaphthalene 
• 96-49-1 [1,3]-dioxolan-2-one 
• 540-51-2 2-bromoethanol 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 60225-63-0 2-(naphthalen-1-yloxy)ethyl 4-toluenesulfonate 
• 90-15-3 α-naphthol 
• 1079252-67-7 ethyl 1-(4-methoxybenzyl)-3-(2-(naphthalen-1-yloxy)ethoxy)-1H-indole-2-carboxylate 
• 50882-68-3 2-(naphthalen-1-yloxy)ethanamine 
• 179030-53-6 Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2-chloro-phenyl ester 2-(naphthalen-1-yloxy)-ethyl ester 
• 525-66-6 propranolol 
• 192652-09-8 1-(2,2-Bis-benzyloxy-ethoxy)-naphthalene 
• 2116-22-5 propanolol 
• 4618-24-0 1-butylamino-3-[1]naphthyloxy-propan-2-ol 
• 50882-69-4 N-methyl-N-[2-(1-naphthyloxy)ethyl]amine 
• 51251-55-9 2-(naphthalen-1-yloxy)ethyl chloride 

Relevant articles and documents

Pseudorotaxane capped mesoporous silica nanoparticles for 3,4-methylenedioxymethamphetamine (MDMA) detection in water

Mesoporous silica nanoparticles loaded with fluorescein and capped by a pseudorotaxane, formed between a naphthalene derivative and cyclobis(paraquat-p-phenylene) (CBPQT4+), were used for the selective and sensitive fluorogenic detection of 3,4-methylenedioxymethamphetamine (MDMA).

Indane derivative and synthetic method and medicinal application thereof

The invention discloses an indane derivative and a synthetic method and medicinal application thereof. The structural general formula is as shown in the specification. The indane derivative disclosed by the invention has excellent inhibitory activity and high selectivity on MAO-B.

Synthesis and inhibitory evaluation of 3-linked imipramines for the exploration of the S2 site of the human serotonin transporter

The human serotonin transporter is the primary target of several antidepressant drugs, and the importance of a primary, high affinity binding site (S1) for antidepressant binding is well documented. The existence of a lower affinity, secondary binding site (S2) has, however, been debated. Herein we report the synthesis of 3-position coupled imipramine ligands from clomipramine using a copper free Sonogashira reaction. Ligand design was inspired by results from docking and steered molecular dynamics simulations, and the ligands were utilized in a structure-activity relationship study of the positional relationship between the S1 and S2 sites. The computer simulations suggested that the S2 site does indeed exist although with lower affinity for imipramine than observed within the S1 site. Additionally, it was possible to dock the 3-linked imipramine analogs into positions which occupy the S1 and the S2 site simultaneously. The structure activity relationship study showed that the shortest ligands were the most potent, and mutations enlarging the proposed S2 site were found to affect the larger ligands positively, while the smaller ligands were mostly unaffected.