21160-53-2

Basic information

• Product Name: [2-(4-BROMO-PHENYL)-THIAZOL-4-YL]-METHANOL
• Synonyms: [2-(4-BROMO-PHENYL)-THIAZOL-4-YL]-METHANOL;[2-(4-broMophenyl)-1,3-thiazol-4-yl]Methanol
• CAS NO: 21160-53-2
• Molecular Formula: C₁₀H₈BrNOS
• Molecular Weight: 270.15
• Mol File: 21160-53-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 412.499 °C at 760 mmHg
• Flash Point: 203.273 °C
• Appearance: /
• Density: 1.614 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: [2-(4-BROMO-PHENYL)-THIAZOL-4-YL]-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(4-BROMO-PHENYL)-THIAZOL-4-YL]-METHANOL(21160-53-2)
• EPA Substance Registry System: [2-(4-BROMO-PHENYL)-THIAZOL-4-YL]-METHANOL(21160-53-2)

Safety Data

• Hazardous Substances Data: 21160-53-2(Hazardous Substances Data)

Usage

General Description

[2-(4-Bromo-phenyl)-thiazol-4-yl]-methanol is a chemical compound with the molecular formula C11H8BrNOS. It is a thiazole derivative and contains a bromo-phenyl group. [2-(4-Bromo-phenyl)-thiazol-4-yl]-methanol has a molecular weight of 291.15 g/mol and is commonly used in organic synthesis and pharmaceutical research. It has potential biological activity and may be used as a building block in the development of new drugs. The chemical structure of [2-(4-Bromo-phenyl)-thiazol-4-yl]-methanol makes it a valuable tool in medicinal chemistry and drug discovery.

Upstream product

• 885278-75-1 ethyl 2-(4-bromophenyl)-1,3-thiazole-4-carboxylate 
• 6704-31-0 oxetan-3-one 
• 26197-93-3 p-bromothiobanzamide 
• 698-67-9 p-bromobenzamide 
• 35199-19-0 4-(chloromethyl)-2-(4-bromophenyl)thiazole 
• 623-00-7 4-bromobenzenecarbonitrile 
• 21166-30-3 2-(4-bromo-phenyl)-thiazole-4-carbaldehyde 

Downstream Products

• 21160-50-9 2-(4-bromophenyl)-1,3-thiazole-4-carboxylic acid 
• 52041-84-6 [5-bromo-2-(4-bromo-phenyl)-thiazol-4-yl]-methanol 
• 21166-30-3 2-(4-bromo-phenyl)-thiazole-4-carbaldehyde 
• 1244030-75-8 2-amino-3-cyano-4-[2-(4-bromophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene 
• 52041-98-2 5-bromo-2-(4-bromo-phenyl)-thiazole-4-carboxylic acid 
• 52041-94-8 5-bromo-2-(4-bromo-phenyl)-thiazole-4-carbaldehyde 

Relevant articles and documents

Design, synthesis and biological evaluation of novel thiazole-derivatives as mitochondrial targeting inhibitors of cancer cells

Mitochondria are pivotal energy production sources for cells to maintain necessary metabolism activities. Targeting dysfunctional mitochondrial features has been a hotspot for mitochondrial-related disease researches. Investigation with cancerous mitochondrial metabolism is a continuing concern within tumor therapy. Herein, we set out to assess the anti-cancer activities of a novel family of TPP-thiazole derivatives based on our earlier research on mitochondrial targeting agents. Specifically, we designed and synthesized a series of TPP-thiazole derivatives and revealed by the MTT assay that most synthesized compounds effectively inhibited three cancer cell lines (HeLa, PC3 and MCF-7). After structure modifications, we explored the SAR relationships and identified the most promising compound R13 (IC50 of 5.52 μM) for further investigation. In the meantime, we performed ATP production assay to assess the selected compounds inhibitory effect on HeLa cells energy production. The results displayed the test compounds significantly restrained ATP production of cancer cells. Overall, we have designed and synthesized a series of compounds which exhibited significant cytotoxicity against cancer cells and effectively inhibited mitochondrial energy production.

Synthesis and biological evaluation of new 2-aryl-4-((4-aryl-1H-1,2,3-triazol-1-yl)methyl)thiazole derivatives

A series of 2-aryl-4-((4-aryl-1H-1,2,3-triazol-1-yl)methyl)thiazole derivatives (8a–p) have been synthesized. The structure of the newly synthesized compounds was determined by spectral analysis. The title compounds were screened for their preliminary ant

Synthesis and in-vitro cytotoxicity of poly-functionalized 4-(2-arylthiazol-4-yl)-4H-chromenes

A new series of 4-aryl-4H-chromenes bearing a 2-arylthiazol-4-yl moiety at the 4-position were prepared as potential cytotoxic agents. The in-vitro cytotoxic activity of the synthesized 4-aryl-4H-chromenes was investigated in comparison with etoposide, a well-known anticancer drug, using MTT colorimetric assay. Among them, the 2-(2-chlorophenyl)thiazol-4-yl analog 4b showed the most potent activity against nasopharyngeal epidermoid carcinoma KB, medulloblastoma DAOY, and astrocytoma 1321N1, and compound 4d bearing a 2-(4-chlorophenyl) thiazol-4-yl moiety at the 4-position of the chromene ring exhibited the best inhibitory activity against breast cancer cells MCF-7, lung cancer cells A549, and colon adenocarcinoma cells SW480 with IC50 values less than 5 μM. The ability of compound 4b to induce apoptosis was confirmed in a nuclear morphological assay by DAPI staining in the KB and MCF-7 cells.