21166-30-3

Usage

Uses

Used in Research and Scientific Studies:
2-(4-Bromo-phenyl)-thiazole-4-carbaldehyde is used as a chemical intermediate for the synthesis of various compounds in research and scientific studies. Its unique structure, which includes a bromine atom, thiazole group, and carbaldehyde functional group, allows it to participate in a wide range of chemical reactions, making it a valuable tool in the development of new chemical entities and materials.
Used in Chemical Reactions:
In the field of organic chemistry, 2-(4-Bromo-phenyl)-thiazole-4-carbaldehyde is used as a reactant in various chemical reactions. The presence of the bromine atom and carbaldehyde group makes it a versatile building block for the synthesis of complex molecules and compounds. Its reactivity can be exploited in reactions such as cross-coupling, reduction, and oxidation processes, leading to the formation of new compounds with potential applications in various industries.
Used in Pharmaceutical Development:
2-(4-Bromo-phenyl)-thiazole-4-carbaldehyde is used as a key component in the development of pharmaceutical compounds. Its unique structure and reactivity make it a promising candidate for the synthesis of new drugs and therapeutic agents. Researchers can utilize its properties to design and synthesize novel molecules with potential medicinal applications, such as antimicrobial, antiviral, or anticancer properties.
Used in Material Science:
In the field of material science, 2-(4-Bromo-phenyl)-thiazole-4-carbaldehyde is used as a precursor in the synthesis of advanced materials. Its structural features and reactivity can be harnessed to create new materials with unique properties, such as improved conductivity, enhanced stability, or novel optical characteristics. These materials can be used in various applications, including electronics, sensors, and energy storage devices.

InChI:InChI=1/C10H6BrNOS/c11-8-3-1-7(2-4-8)10-12-9(5-13)6-14-10/h1-6H

Upstream product

• 35199-19-0 4-(chloromethyl)-2-(4-bromophenyl)thiazole 
• 21160-53-2 2-(4-bromophenyl)-4-hydroxymethylthiazole 
• 26197-93-3 p-bromothiobanzamide 
• 623-00-7 4-bromobenzenecarbonitrile 
• 885278-75-1 ethyl 2-(4-bromophenyl)-1,3-thiazole-4-carboxylate 
• 534-07-6 1,3-Dichloroacetone 

Downstream Products

• 138019-78-0 (Z)-3-[2-(4-Bromo-phenyl)-thiazol-4-yl]-1-(2-hydroxy-phenyl)-propenone 
• 174006-76-9 2-(4-Bromo-phenyl)-thiazole-4-carbonitrile 
• 174006-81-6 2-(4-Bromo-phenyl)-thiazole-4-carbothioic acid amide 
• 138019-88-2 2-[2-(4-Bromo-phenyl)-thiazol-4-yl]-3-hydroxy-chromen-4-one 
• 138019-83-7 Acetic acid 2-{(Z)-3-[2-(4-bromo-phenyl)-thiazol-4-yl]-acryloyl}-phenyl ester 
• 138019-93-9 Acetic acid 2-[2-(4-bromo-phenyl)-thiazol-4-yl]-4-oxo-4H-chromen-3-yl ester 
• 1244030-75-8 2-amino-3-cyano-4-[2-(4-bromophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene 
• 64953-97-5 1-(2-p-bromophenylthiazol-4-yl)ethanol 
• 174006-72-5 2-(4-Bromo-phenyl)-thiazole-4-carbaldehyde oxime 
• 21160-50-9 2-(4-bromophenyl)-1,3-thiazole-4-carboxylic acid 
• 21160-53-2 2-(4-bromophenyl)-4-hydroxymethylthiazole 
• 21166-40-5 1-[2-(4-bromo-phenyl)-thiazol-4-yl]-ethanone 

Relevant academic research and scientific papers

Synthesis of new 2-(thiazol-4-yl)thiazolidin-4-one derivatives as potential anti-mycobacterial agents

To search for potent antimycobacterial lead compounds, a new series of 3-substituted phenyl-2-(2-(substituted phenyl)thiazol-4-yl) thiazolidin-4-one (5a-t) derivatives have been synthesized by the condensation of 2-substituted phenyl thiazole-4-carbaldehy

Heterocycles 38. Biocatalytic synthesis of new heterocyclic mannich bases and derivatives

This paper describes the biocatalytic synthesis of new Mannich bases containing various heterocyclic rings (thiazole, furane, thiophene, pyridine) by applying the lipase catalyzed trimolecular condensation of the corresponding heterocyclic aldehydes with acetone and primary aromatic amines, in mild and eco-friendly reaction conditions. The obtained Mannich bases were acylated to their corresponding N-acetyl derivatives. All compounds were characterized by 1H-NMR, 13C-NMR and MS spectrometry.

Heterocycles 32. Efficient kinetic resolution of 1-(2-arylthiazol-4-yl) ethanols and their acetates using lipase B from Candida antarctica

In this paper we describe the chemoenzymatic synthesis of new enantiomerically enriched (R)- and (S)-1-(2-arylthiazol-4-yl)ethanols and their acetates by enzymatic enantioselective acetylation of the racemic alcohols rac-2a-d and by methanolysis of the corresponding racemic esters rac-3a-d mediated by lipase B from Candida antarctica (CaL-B) in non-aqueous media. In terms of stereoselectivity and activity, both procedures, acylation and alcoholysis, gave similar good results (50% conversion, E 〉 200). The absolute configuration of the kinetic resolution products was determined by a detailed 1H NMR study of the Mosher's derivatives of (S)-2b.

Synthesis and in-vitro cytotoxicity of poly-functionalized 4-(2-arylthiazol-4-yl)-4H-chromenes

A new series of 4-aryl-4H-chromenes bearing a 2-arylthiazol-4-yl moiety at the 4-position were prepared as potential cytotoxic agents. The in-vitro cytotoxic activity of the synthesized 4-aryl-4H-chromenes was investigated in comparison with etoposide, a well-known anticancer drug, using MTT colorimetric assay. Among them, the 2-(2-chlorophenyl)thiazol-4-yl analog 4b showed the most potent activity against nasopharyngeal epidermoid carcinoma KB, medulloblastoma DAOY, and astrocytoma 1321N1, and compound 4d bearing a 2-(4-chlorophenyl) thiazol-4-yl moiety at the 4-position of the chromene ring exhibited the best inhibitory activity against breast cancer cells MCF-7, lung cancer cells A549, and colon adenocarcinoma cells SW480 with IC50 values less than 5 μM. The ability of compound 4b to induce apoptosis was confirmed in a nuclear morphological assay by DAPI staining in the KB and MCF-7 cells.