211615-68-8

Upstream product

• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 5720-07-0 4-methoxyphenylboronic acid 
• 159590-01-9 2,4,5-tribromo-1-<<2-(trimethylsilyl)ethoxy>methyl>-1H-imidazole 

Downstream Products

• 1448032-63-0 2-(4-methoxyphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-4,5-di(2-tolyl)-1H-imidazole 
• 1728-95-6 2-(4-methoxy-phenyl)-4,5-diphenyl-1H-imidazole 
• 1448032-62-9 2-(4-methoxyphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-4,5-diphenyl-1H-imidazole 

Relevant academic research and scientific papers

Selective sequential cross-coupling reactions on imidazole towards neurodazine and analogues

Polysubstituted imidazoles represent a common structural motif in bioactive molecules. A modular and flexible strategy towards 2,4,5-triarylated imidazoles is reported applying a Suzuki-Miyaura cross-coupling protocol. Employing 1-protected 2,4,5-tribromoimidazole as starting material, both stepwise and one-pot protocols towards the title compounds are disclosed. The utility of the approach was demonstrated by synthesizing neurodazine, a biologically active molecule affecting neuronal cell differentiation.