21182-01-4Relevant articles and documents
Combined Iron/Hydroxytriazole Dual Catalytic System for Site Selective Oxidation Adjacent to Azaheterocycles
Cooper, Julian C.,Luo, Chaosheng,Kameyama, Ryohei,Van Humbeck, Jeffrey F.
supporting information, p. 1243 - 1246 (2018/02/09)
This report details a new method for site-selective methylene oxidation adjacent to azaheterocycles. A dual catalysis approach, utilizing both an iron Lewis acid and an organic hydroxylamine catalyst, proved highly effective. We demonstrate that this method provides complementary selectivity to other known catalytic approaches and represents an improvement over current heterocycle-selective reactions that rely on stoichiometric activation.
Phosphorus oxychloride as an efficient coupling reagent for the synthesis of esters, amides and peptides under mild conditions
Chen, Hu,Xu, Xunfu,Liu, Liu,Tang, Guo,Zhao, Yufen
, p. 16247 - 16250 (2013/09/23)
A mild method is described for the conversion of carboxylic acids into esters, amides, as well as peptides without racemization through carboxyl activation by the reagent combination of POCl3 and DMAP. Long chain alcohols could be converted to the corresponding ester in good yields. 31P NMR spectrum was used to detect phosphorus-containing intermediates in ongoing reactions directly, and a possible mechanism has been proposed based on these results. The Royal Society of Chemistry 2013.
HYDROLYSIS OF N-METHYLNICOTINYL AND N-METHYLISONICOTINYL ESTERS AND SOME n-PARTICIPATING DERIVATIVES UNDER MICELLAR CONDITIONS
Jursic, Branko,Ladika, Mladen,Sunko, Dionis E.
, p. 1955 - 1968 (2007/10/02)
Hydrolysis rate of two types of compounds, A and B were studied in the presence of variable concentrations of an anionic surfactant (sodium dodecylsulfate, SDS).Class A of compounds consists of substances which hydrolyze by the SN1 mechanism and which are
