21192-61-0

Basic information

• Product Name: Benzeneacetonitrile, 4-benzoyl-
• Synonyms: 4-cyanomethylbenzophenone;Benzeneacetonitrile,4-benzoyl;p-benzoylphenylacetonitrile
• CAS NO: 21192-61-0
• Molecular Formula: C15H11NO
• Molecular Weight: 221.258
• Mol File: 21192-61-0.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzeneacetonitrile, 4-benzoyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, 4-benzoyl-(21192-61-0)
• EPA Substance Registry System: Benzeneacetonitrile, 4-benzoyl-(21192-61-0)

Safety Data

• Hazardous Substances Data: 21192-61-0(Hazardous Substances Data)

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 32752-54-8 4-(bromomethyl)benzophenone 
• 773837-37-9 sodium cyanide 
• 42728-62-1 4-chloromethylbenzophenone 
• 876-08-4 p-(chloromethyl)benzoyl chloride 
• 98-80-6 phenylboronic acid 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 
• 1071-36-9 sodium cyanoacetate 
• 134-84-9 4-Methylbenzophenone 
• 18293-53-3 2-trimethylsilylacetonitrile 
• 143-33-9 sodium cyanide 
• 151-50-8 potassium cyanide 

Downstream Products

• 1356067-51-0 (+/-)-oxiran-2-ylmethyl 2-(4-benzylphenyl)acetate 
• 1356067-55-4 (±)-tetrahydro-2H-pyran-2-ylmethyl (4-benzylphenyl)acetate 
• 1356067-61-2 (2R)-(-)-oxiran-2-ylmethyl 2-(4-benzylphenyl)acetate 
• 1356067-62-3 (2S)-(+)-oxiran-2-ylmethyl 2-(4-benzylphenyl)acetate 
• 1356067-64-5 2-hydroxy-1-(hydroxymethyl)ethyl 2-(4-benzylphenyl)acetate 
• 1356067-69-0 2-(benzyloxy)-1-[(benzyloxy)methyl]ethyl 2-(4-benzylphenyl)acetate 
• 35889-03-3 2-(4-benzylphenyl)acetic acid 
• 24021-61-2 2-(4-benzoyl-phenyl)-2-methyl-propionic acid methyl ester 
• 170750-77-3 (4-Benzoyl-phenyl)-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 412049-87-7 5-[propargyl{2-(4-benzoylphenyl)acetamido}]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-uridine 
• 412049-86-6 2-(4-benzoylphenyl)-N-prop-2-ynylethanamide 

Relevant articles and documents

SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1

The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): (Iar) wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Palladium-catalyzed and copper-mediated cross-coupling reaction of aryl- or alkenylboronic acids with acid chlorides under neutral conditions: Efficient synthetic methods for diaryl ketones and chalcones at room temperature

Palladium-catalyzed cross-coupling reaction of aryl- or alkenylboronic acids with acid chlorides in the presence of copper(I) thiophene-2-carboxylate (CuTC) as an activator in diethyl ether at room temperature under strictly non-basic conditions affords the diaryl ketones or chalcones in moderate to excellent yields. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on the aromatic ring are compatible.

Synthesis of α-Aryl nitriles through palladium-catalyzed decarboxylative coupling of cyanoacetate salts with aryl halides and triflates

Worth its salt: The palladium-catalyzed decarboxylative coupling of the cyanoacetate salt as well as its mono- and disubstituted derivatives with aryl chlorides, bromides, and triflates is described (see scheme). This reaction is potentially useful for the preparation of a diverse array of α-aryl nitriles and has good functional group tolerance. S-Phos=2-(2,6- dimethoxybiphenyl)dicyclohexylphosphine), Xant-Phos=4,5-bis(diphenylphosphino)- 9,9-dimethylxanthene. Copyright