21193-61-3

Basic information

• Product Name: 5-bromo-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• Synonyms: 7H-pyrrolo[2,3-d]pyrimidin-4-amine, 5-bromo-7-beta-D-ribofuranosyl-; Bromotubercidin
• CAS NO: 21193-61-3
• Molecular Formula: C₁₁H₁₃BrN₄O₄
• Molecular Weight: 345.1493
• Mol File: 21193-61-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 686.9°C at 760 mmHg
• Flash Point: 369.2°C
• Density: 2.26g/cm³
• Vapor Pressure: 8.16E-20mmHg at 25°C
• Refractive Index: 1.869
• CAS DataBase Reference: 5-bromo-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(21193-61-3)
• EPA Substance Registry System: 5-bromo-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(21193-61-3)

Safety Data

• Hazardous Substances Data: 21193-61-3(Hazardous Substances Data)

Upstream product

• 952429-11-7 (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diyl dibenzoate 
• 952429-12-8 5-bromo-4-chloro-7-(2,3,5-tri-O-benzoyl-β-L-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 22276-95-5 5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine 
• 60343-84-2 2',3',5'-tri-O-acetyltubercidin 

Downstream Products

• 69-33-0 tubercidin 
• 40725-89-1 4-amino-N7-(3'-deoxy-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine 
• 1428254-19-6 (2R,3R,4R,5R)-2-(4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(chloromethyl)tetra-hydrofuran-3,4-diol 

Relevant articles and documents

Chemical synthesis and biological activity of novel brominated 7-deazaadenosine-3′,5′-cyclic monophosphate derivatives

Synthetic derivatives of cyclic adenosine monophosphate, such as halogenated or other more hydrophobic analogs, are widely used compounds, to investigate diverse signal transduction pathways of eukaryotic cells. This inspired us to develop cyclic nucleoti

A containing spiro group of the pyrrolo [2, 3 - d] pyrimidine compound and its preparation method

The present invention provides a formula (I) of the formula (II) is shown including volute group of the pyrrolo [2, 3 - d] pyrimidine compounds and their pharmaceutically acceptable salt, and method of preparation and application. Compounds of this class

NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS

The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.