21209-63-2Relevant academic research and scientific papers
Iridium-Catalyzed Acid-Assisted Hydrogenation of Oximes to Hydroxylamines
Cope, Christopher J.,Cramer, Nicolai,Mas-Roselló, Josep,Pinson, Benjamin,Robinson, Alan,Smejkal, Tomas,Tan, Eric
supporting information, p. 15524 - 15532 (2021/06/11)
We found that cyclometalated cyclopentadienyl iridium(III) complexes are uniquely efficient catalysts in homogeneous hydrogenation of oximes to hydroxylamine products. A stable iridium C,N-chelation is crucial, with alkoxy-substituted aryl ketimine ligand
Synthesis of N-Hydroxy-α-amino Acids by Alkylation of N-Benzylidene-α-amino Acid Methyl Ester N-oxides
Lau, Hans-Hermann,Schoellkopf, Ulrich
, p. 1378 - 1387 (2007/10/02)
The higher N-benzylidene-α-amino acid methyl ester N-oxides 3c-t were obtained from the lower nitrone esters 3a and b by base induced alkylation in α-position of the N->O-group.The compounds 3 were converted into the N-hydroxy-α-amino acid methyl esters 6 by heating with hydroxylamine hydrochloride in ethanol and into N-hydroxy-α-amino acids 7 with concd. hydrochloric acid. - Compound 3d was, on heating in toluene, converted to methyl 1-aza-7-oxabicycloheptanecarboxylate 8 by intramolecular cycloaddition.
