70288-60-7Relevant articles and documents
Deacetylation of α-bromo-α-substituted-acetoacetates
Hu, Youhong,Bai, Donglu
, p. 2375 - 2376 (1998)
A new and efficient method for the deacetylation of α-bromo-α- substituted-acetoacetates to obtain α-bromoesters has been achieved by treatment with LiClO4/Et3N in ether at room temperature.
ANTIVIRAL COMPOUNDS
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, (2019/04/27)
The present invention relates to novel compounds of general formula (I) wherein R1 to R4 and n have the meanings given in the description and claims, process for preparing these compounds and their use as for treating, preventing or ameliorating viral infections and their use for treating, preventing or ameliorating diseases which are associated with PLA2G16.
Diastereo- And Enantioselective Synthesis of Quaternary α-Amino Acid Precursors by Copper-Catalyzed Propargylation
Zhu, Qiongqiong,Meng, Beibei,Gu, Congzheng,Xu, Ye,Chen, Jie,Lei, Chuanhu,Wu, Xiaoyu
supporting information, p. 9985 - 9989 (2019/12/24)
A diastereo- and enantioselective propargylic substitution reaction between propargylic carbonates and α-substituted nitroacetates catalyzed by a Cu-pybox complex is described. This method allows the preparation of a series of non-proteinogenic quaternary α-amino acid precursors featuring two contiguous stereogenic centers and a terminal alkyne moiety in high yields with good to excellent diastereo- and enantioselectivities in most cases. The propargylated adducts were elaborated into a diverse set of quaternary α-amino acid derivatives.