212199-01-4Relevant academic research and scientific papers
Synthesis of four spacer-containing 'tetrasaccharides' that represent four possible repeating units of the capsular polysaccharide of Streptococcus pneumoniae type 6B
Thijssen, Mark-J. L.,Bijkerk, Menno H. G.,Kamerling, Johannis P.,Vliegenthart, Johannes F. G.
, p. 111 - 125 (2007/10/03)
In the framework of studies towards oligosaccharide-conjugate based vaccines against Streptococcus pneumoniae, the synthesis is reported of four spacer-containing 'tetrasaccharides' that each can be conceived as representing a repeating unit of the capsular polysaccharide of S. pneumoniae serotype 6B, namely, 3-aminopropyl D-ribityl-(5 → hydrogen phosphate → 2)- α-D-galactopyranosyl-(1 → 3)-α-D-glucopyranosyl-(1 → 3)-α-L- rhamnopyranoside, 3-aminopropyl α-L-rhamnopyranosyl-(1 → 4)-D-ribityl-(5 → hydrogen phosphate → 2)-α-D-galactopyranosyl-(1 → 3)-α-D-glucopyranoside, 3-aminopropyl α-D-glucopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 4)-D- ribityl-(5 → hydrogen phosphate → 2)-α-D-galactopyranoside, and α-D- galactopyranosyl-(1 → 3)-α-D-glucopyranosyl-(1 → 3)-α-L-rhamnopyranosyl- (1 → 4)-5-O-(3-aminopropyl hydrogen phosphate)-D-ribitol. Phosphorylations were carried out using the H-phosphonate method.
