212268-46-7Relevant academic research and scientific papers
Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
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, (2008/06/13)
The invention relates to compounds of the formulas 1 and 2 and to pharmaceutically acceptable salts and hydrates thereof, wherein X1, R1, R2and R11are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formulas 1 and 2 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formulas 1 and 2.
Selective N-alkylation of pyrrolopyrimidines and indoles by 'transfer of activation'
Sobolov, Susan B.,Sun, Jianmin,Cooper, Beth A.
, p. 5685 - 5688 (2007/10/03)
The benzene sulfonyl group is used as a 'transfer of activation' reagent to alkylate selectively the NH of both pyrrolopyrimidines and 5-aminoindoles substituted on thienopyrimidines. A variety of primary and secondary alcohols are utilized as alkylating
