2123-27-5

Usage

Uses

Used in Polymer and Resin Production:
2,4-dichlorostyrene is utilized as a monomer in the synthesis of various polymers and resins for [application reason]. Its chemical structure allows it to be polymerized into plastics and resins that possess specific properties, such as durability and resistance to certain environmental conditions.
Used in Plastic and Polymer Product Manufacturing:
In the Plastics Industry, 2,4-dichlorostyrene is used as a key component in the production of plastic materials for [application reason]. The resulting polymers are employed in a wide range of applications, including construction, automotive, and consumer goods, due to their versatility and performance characteristics.
Used in Industrial Settings:
2,4-dichlorostyrene is primarily used in industrial applications where its chemical properties are harnessed to create a variety of plastic and polymer products for [application reason]. Its presence in these products is essential for achieving desired material properties that meet specific industry standards and performance requirements.

InChI:InChI=1/C8H6Cl2/c1-2-6-3-4-7(9)5-8(6)10/h2-5H,1H2

Upstream product

• 1201-99-6 trans-2,4-dichlorocinnamic acid 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 2234-16-4 1-(2,4-dichlorophenyl)ethan-1-one 
• 16532-02-8 bromomethyldimethylsilyl chloride 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 81156-68-5 2,4-dichlorophenylethyl alcohol 
• 1475-13-4 2,4-dichloro-α-methylbenzyl alcohol 

Downstream Products

• 121222-45-5 2,4-dichlorophenyl-1,2-ethanediol dinitrate 
• 2234-16-4 1-(2,4-dichlorophenyl)ethan-1-one 
• 930781-40-1 2-(2,4-dichloroyphenyl)quinoxaline 
• 13692-15-4 2-(2,4-dichlorophenyl)oxirane 
• 1335126-62-9 (R)-((R)-1-phenyl-2,2,2-trichloroethyl) 2-(2,4-dichlorophenyl)aziridine-1-carboxylate 
• 1046403-92-2 5-[(E)-2-(2,4-dichloro-phenyl)-vinyl]-2-propionylamino-benzoic acid methyl ester 

Relevant academic research and scientific papers

Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus

Antibiotic resistance among clinically significant bacterial pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant S. aureus (VRSA) is becoming a prevalent threat to public health, and new antibacterial agents with novel mechanisms of action hence are in an urgent need. As a part of continuing effort to develop antibacterial agents, we rationally designed and synthesized two series of 4,5-dihydroisoxazol-5-yl and 4,5-dihydroisoxazol-3-yl-containing benzamide derivatives that targeted the bacterial cell division protein FtsZ. Evaluation of their activity against a panel of Gram-positive and -negative pathogens revealed that compound A16 possessing the 4,5-dihydroisoxazol-5-yl group showed outstanding antibacterial activity (MIC, ≤0.125–0.5 μg/mL) against various testing strains, including methicillin-resistant, penicillin-resistant and clinical isolated S. aureus strains. Besides, further mouse infection model revealed that A16 could be effective in vivo and non-toxic to Hela cells. Finally, a detailed discussion of structure-activity relationships was conducted, referring to the docking results. It is worth noting that substituting a 4,5-dihydroisoxazole ring for the isoxazole ring not only broadened the antibacterial spectrum but also resulted in a significant increase in antibacterial activity against S. aureus strains. Taken together, these results suggest a promising chemotype for the development of new FtsZ-targeting bactericidal agents.

Oxidative trifluoromethylation and fluoroolefination of unactivated olefins

Fluorine-containing organic compounds are gaining increasing importance in medicinal chemistry. Described herein is a mild and efficient method for the radical addition of olefins with TMSCF3 and TMSCF2R (R = COOEt or CF3) to deliver various α-trifluoromethylated ketones and α-fluoroolefinated ketones.

Highly selective Wacker reaction of styrene derivatives: A green and efficient aerobic oxidative process promoted by benzoquinone/NaNO 2/HClO4 under mild conditions

A green and efficient catalytic redox system for the aerobic oxidative Wacker oxidation of styrene derivatives at room temperature using molecular oxygen as the terminal oxidant without copper chloride has been developed. The newly developed system exhibited excellent catalytic activity for the smooth transformation of terminal styrene derivatives to the desired methyl ketones with up to 96% yield and >99% selectivity. The Royal Society of Chemistry 2013.

Olefin-assisted iron-catalyzed alkylation of aryl chlorides

A selective and operationally simple ironcatalyzed cross-coupling of aryl chlorides with alkylmagnesium halides has been developed. The reaction tolerates various functional groups and exhibits high chemoselectivity even in the presence of aryl bromides. Mechanistic studies indicate the essential role of the olefin substituent for substrate activation. Competing polymerization and reduction are effectively suppressed.

Chlorostyrenes in iron-catalyzed biaryl coupling reactions

An effective protocol for iron-catalyzed biaryl syntheses by coupling chlorostyrenes with aryl Grignard reagents requires only mild reaction conditions and tolerates various functional groups. The underlying activation of deactivated aryl chlorides proceeds through a rate-determining coordination of the catalyst to the vinyl substituent and subsequent haptotropic migration along the conjugated πsystem to the site of C-Cl bond cleavage. Copyright

Selective 5-hydroxytryptamine 2c receptor agonists derived from the lead compound tranylcypromine: Identification of drugs with antidepressant-like action

We report here the design, synthesis, and pharmacological properties of a series of compounds related to tranylcypromine (9), which itself was discovered as a lead compound in a high-throughput screening campaign. Starting from 9, which shows modest activity as a 5-HT2C agonist, a series of 1-aminomethyl-2- phenylcyclopropanes was investigated as 5-HT2C agonists through iterative structural modifications. Key pharmacophore feature of this new class of ligands is a 2-aminomethyl-trans-cyclopropyl side chain attached to a substituted be zene ring. Among the tested compounds, several were potent and efficacious 5-HT2C receptor agonists with selectivity over both 5-HT2A and 5-HT2B receptors in functional assays. The most promising compound is 37, with 120- and 14-fold selectivity over 5-HT 2A and 5-HT2B, respectively (EC50) 585, 65, and 4.8 nM at the 2A, 2B, and 2C subtypes, respectively). In animal studies, compound 37 (10-60 mg/kg) decreased immobility time in the mouse forced swim test.

Synthesis and olefination of carbonyl compounds using solid-supported reagents

The development and application of three new solid-supported reagents for use in the synthesis or olefination of carbonyl compounds are described. The reagents include the Weinreb amide, Mukaiyama's S-2-pyridyl thioate and a Peterson methylenation reagent. As solid-supports p-benzyl alcohol resin, Wang resin and Merrifield resin (1-2% crosslinked polystyrene) have been used. The Royal Society of Chemistry.

Pinacolboratamethyl-enetriphenylphosphonium iodide, a new methylene transfer reagent

The title compound is easily prepared and reacts with various aldehydes and ketone. The reagent is compatible with free hydroxy groups. Yields with various aldehydes and ketones are in 50- > 99% range. Both aliphatic, aromatic and unsaturated carbonyls react.

Copper(I)-catalyzed intramolecular cyclization reaction of 2-(2'- chlorophenyl)ethanol to give 2,3-dihydrobenzofuran

Functionalized 2,3-dihydrobenzofuran can be synthesized in good yield via an intramolecular cyclization of an aryl chloride and a primary alcohol under the catalysis of copper(I) chloride salt. (C) 2000 Elsevier Science Ltd.