2123-28-6

Basic information

• Product Name: 1,2-Dichloro-3-vinylbenzene
• Synonyms: 1,2-Dichloro-3-vinylbenzene;2,3-Dichlorostyrene
• CAS NO: 2123-28-6
• Molecular Formula: C₈H₆Cl₂
• Molecular Weight: 173.0392
• Mol File: 2123-28-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 48.5°C (estimate)
• Boiling Point: 230.44°C (rough estimate)
• Flash Point: 99.1°C
• Appearance: /
• Density: 1.2640
• Vapor Pressure: 0.076mmHg at 25°C
• Refractive Index: 1.5848 (estimate)
• CAS DataBase Reference: 1,2-Dichloro-3-vinylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Dichloro-3-vinylbenzene(2123-28-6)
• EPA Substance Registry System: 1,2-Dichloro-3-vinylbenzene(2123-28-6)

Safety Data

• Hazardous Substances Data: 2123-28-6(Hazardous Substances Data)

Usage

General Description

1,2-Dichloro-3-vinylbenzene, also known as o-dichlorostyrene, is a chemical compound with the formula C8H6Cl2. It is a clear, colorless to pale yellow liquid with a pungent odor. This chemical is primarily used as a reagent in chemical synthesis and as an intermediate in the production of polymers and resins. It is also used in the manufacturing of specialty chemicals and pharmaceuticals. 1,2-Dichloro-3-vinylbenzene is considered to have moderate toxicity, and exposure to this compound can cause irritation to the eyes, skin, and respiratory system. It may also have harmful effects on aquatic organisms. Due to its potential hazards, proper handling and safety measures should be implemented when working with this chemical.

InChI:InChI=1/C8H6Cl2/c1-2-6-4-3-5-7(9)8(6)10/h2-5H,1H2

Upstream product

• 100-41-4 ethylbenzene 
• 7782-50-5 chlorine 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 6334-18-5 2,3-dichlorobenzylaldehyde 

Downstream Products

• 1335126-67-4 (R)-((R)-1-phenyl-2,2,2-trichloroethyl) 2-(2,3-dichlorophenyl)aziridine-1-carboxylate 
• 1346010-25-0 C₁₇H₂₀Cl₂O₃ 

Relevant articles and documents

Selective 5-hydroxytryptamine 2c receptor agonists derived from the lead compound tranylcypromine: Identification of drugs with antidepressant-like action

We report here the design, synthesis, and pharmacological properties of a series of compounds related to tranylcypromine (9), which itself was discovered as a lead compound in a high-throughput screening campaign. Starting from 9, which shows modest activity as a 5-HT2C agonist, a series of 1-aminomethyl-2- phenylcyclopropanes was investigated as 5-HT2C agonists through iterative structural modifications. Key pharmacophore feature of this new class of ligands is a 2-aminomethyl-trans-cyclopropyl side chain attached to a substituted be zene ring. Among the tested compounds, several were potent and efficacious 5-HT2C receptor agonists with selectivity over both 5-HT2A and 5-HT2B receptors in functional assays. The most promising compound is 37, with 120- and 14-fold selectivity over 5-HT 2A and 5-HT2B, respectively (EC50) 585, 65, and 4.8 nM at the 2A, 2B, and 2C subtypes, respectively). In animal studies, compound 37 (10-60 mg/kg) decreased immobility time in the mouse forced swim test.