21232-38-2

Upstream product

• 133901-52-7 N-[2-(1-phenylethenyl)phenyl]acetamide 
• 85864-33-1 phenyl(2-pivaloylamidophenyl)methane 
• 28059-64-5 2-benzylaniline 
• 1325765-75-0 C₁₉H₂₃NO 

Downstream Products

• 1325765-81-8 1,3-bis[2-(1-phenyl-ethyl)-phenyl]-1H-imidazolium chloride 
• 1325765-76-1 (R)-1-(1-(2-bromophenyl)ethyl)benzene 
• 1325765-77-2 (S,S)-1,2-diphenyl-N,N'-bis[(R)-2-(1-phenyl-ethyl)-phenyl]-ethane-1,2-diamine 

Relevant academic research and scientific papers

Bicyclic Bridgehead Phosphoramidite-Based Hybrid Diphosphorus Ligands: Design, Synthesis, and Application in Catalytic Asymmetric Hydrogenation

A strategy for chiral ligand design has been developed that allows for incorporation of an achiral bicyclic bridgehead phosphoramidite to generate a class of hybrid diphosphorus ligands for high activity and asymmetric control. Using this concept, a series of chiral phosphine-phosphoramidite ligands bearing the sole chirality at the ligand backbone have been prepared and successfully employed in the Rh-catalyzed asymmetric hydrogenation of 2-vinylanilides for the synthesis of optically active anilines bearing an ortho-tertiary benzylic stereocenter.

Branch-Selective and Enantioselective Iridium-Catalyzed Alkene Hydroarylation via Anilide-Directed C-H Oxidative Addition

Tertiary benzylic stereocenters are accessed in high enantioselectivity by Ir-catalyzed branch selective addition of anilide ortho-C-H bonds across styrenes and α-olefins. Mechanistic studies indicate that the stereocenter generating step is reversible.

Design and synthesis of C2-symmetric N-heterocyclic carbene precursors and metal carbenoids

Chiral, C2-symmetric imidazolium and imidazolinium ions, as well as the corresponding copper- or silver-bound carbenoids, have been prepared. Structural study of these compounds by X-ray crystallography reveals a chiral pocket that surrounds th