133901-52-7Relevant academic research and scientific papers
Palladium(ii)-catalyzed vinylic geminal double C-H activation and alkyne annulation reaction: Synthesis of pentafulvenes
Phukon, Jyotshna,Gogoi, Sanjib
supporting information, p. 1133 - 1136 (2020/02/04)
The first transition-metal-catalyzed vinylic geminal double C(sp2)-H activation and di-substituted alkyne annulation reaction is reported. This palladium(ii)-catalyzed, amide directed reaction of vinylic compounds with di-substituted alkynes offers an efficient synthetic path to pentafulvenes, which are very important compounds because of their bioactivity and interesting optical properties. A FeCl3-mediated transformation of pentafulvenes to fluorescent cyclopenta[b]quinolines is also developed.
Metal-free synthesis of 2-fluoroalkylated quinolines using polyfluoroalkanoic acids as direct fluorine sources
Nan, Jiang,Hu, Yan,Chen, Pu,Ma, Yangmin
supporting information, p. 1984 - 1988 (2019/03/26)
A novel [5 + 1] cyclization of 2-vinylanilines with polyfluoroalkanoic acids under catalyst- A nd additive-free conditions was successfully implemented. The approach directly employs very low-cost and readily available polyfluoroalkanoic acids as both C1 synthons and fluoroalkyl building blocks. This method provides concise access to diverse 2-fluoroalkylated (CF3, C2F5, C3F7, CF2H, CF2Cl, and CF2Br) quinolines in good yields with excellent functional group tolerance in high yield on a gram scale.
Iridium-Catalyzed α-Selective Arylation of Styrenes by Dual C?H Functionalization
Cooper, Phillippa,Crisenza, Giacomo E. M.,Feron, Lyman J.,Bower, John F.
supporting information, p. 14198 - 14202 (2018/10/02)
An IrI-system modified with a ferrocene derived bisphosphine ligand promotes α-selective arylation of styrenes by dual C?H functionalization. These studies offer a regioisomeric alternative to the Pd-catalyzed Fujiwara–Moritani reaction.
Palladium-Catalyzed Coupling of Sulfonylhydrazones with Heteroaromatic 2-Amino-Halides (Barluenga Reaction): Exploring the Electronics of the Sulfonylhydrazone
Tan, Hongyu,Houpis, Ioannis,Liu, Renmao,Wang, Youchu,Chen, Zhilong,Fleming, Matthew J.
supporting information, p. 1044 - 1048 (2015/09/01)
This paper describes a new reactivity of the Pd-catalyzed coupling of 2-amino-3-bromo-aromatic and heteroaromatic compounds with sulfonylhydrazones (Barluenga reaction).The new catalyst system and modulation of the electronic nature of hydrazone that were needed for successful reaction are described herein.
Synthesis of benzazetine derivatives by intramolecular iodoamination of o-(acylamino)styrene derivatives
Kobayashi, Kazuhiro,Miyamoto, Kazuna,Morikawa, Osamu,Konishi, Hisatoshi
, p. 886 - 889 (2007/10/03)
The iodoamination of o-(acylamino)styrene derivatives using iodine and sodium hydrogencarbonate, producing 7-acyl-8-iodomethylbicyclo[4.2.0]-7-azaoct- 1,3,5-triene [1-acyl-2-(iodomethyl)benzazetine] derivatives, is described. Replacement of the iodo moiety by hydrogen or phenylthio group is also reported.
Regiochemistry of Radical Cyclisations (6-exo/7-endo and 7-exo/8-endo) of N-(o-Alkenylphenyl)-2,2-dichloroacetamides
Sato, Tatsunori,Ishida, Satoshi,Ishibashi, Hiroyuki,Ikeda, Masazumi
, p. 353 - 359 (2007/10/02)
N--2,2-dichloroacetamides, when treated with 2.2 mol-equiv. of Bu3SnH in the presence of a catalytic amount of azoisobutyronitrile, gave quinolin-2(1H)-one (6-exo closure) and/or 2H-1-benzazepin-2-one (7-endo closure) systems.In gene
